Cell type atlas - TOX4 - The Human Protein Atlas

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TOX4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOX4
Gene descriptionⁱ Full gene name according to HGNC.	TOX high mobility group box family member 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	37 NX
Colon	51 NX
Kidney	31 NX
Liver	22 NX

Basal glandular cells	56 NX
Prostate	56 NX

Basal keratinocytes	78 NX
Skin	78 NX

Bipolar cells	76 NX
Eye	76 NX

Cardiomyocytes	45 NX
Heart muscle	45 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	56 NX
Lung	56 NX

Club cells	53 NX
Lung	53 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	66 NX
Placenta	66 NX

Distal tubular cells	53 NX
Kidney	53 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	55 NX
Testis	55 NX

Endothelial cells	48 NX
Prostate	78 NX
Testis	55 NX
Pancreas	54 NX
Skin	52 NX
Lung	50 NX
Liver	45 NX
Eye	44 NX
Placenta	43 NX
Heart muscle	39 NX

Enterocytes	50 NX
Small intestine	70 NX
Colon	47 NX
Rectum	46 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	45 NX
Pancreas	45 NX

Extravillous trophoblasts	54 NX
Placenta	54 NX

Fibroblasts	46 NX
Prostate	65 NX
Lung	59 NX
Skin	49 NX
Placenta	43 NX
Heart muscle	32 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	59 NX
Lung	72 NX
Colon	46 NX

Hepatocytes	40 NX
Liver	40 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	66 NX
Colon	71 NX
Rectum	61 NX

Ito cells	33 NX
Liver	33 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	27 NX
Testis	27 NX

Leydig cells	45 NX
Testis	45 NX

Macrophages	51 NX
Skin	60 NX
Pancreas	52 NX
Prostate	51 NX
Lung	50 NX
Testis	47 NX
Kidney	44 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	54 NX
Pancreas	54 NX

Mucus-secreting cells	38 NX
Small intestine	45 NX
Colon	43 NX
Rectum	35 NX

Muller glia cells	48 NX
Eye	48 NX

Pancreatic endocrine cells	42 NX
Pancreas	42 NX

Paneth cells	41 NX
Small intestine	67 NX
Rectum	41 NX
Colon	35 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	47 NX
Eye	47 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	52 NX
Prostate	75 NX
Skin	62 NX
Pancreas	52 NX
Heart muscle	30 NX

Spermatocytes	104 NX
Testis	104 NX

Spermatogonia	55 NX
Testis	55 NX

Suprabasal keratinocytes	78 NX
Skin	78 NX

Syncytiotrophoblasts	222 NX
Placenta	222 NX

T-cells	66 NX
Colon	82 NX
Prostate	70 NX
Kidney	69 NX
Lung	66 NX
Liver	61 NX
Skin	60 NX

Undifferentiated cells	38 NX
Small intestine	41 NX
Rectum	38 NX
Colon	37 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.