Cell type atlas - FH - The Human Protein Atlas

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FH

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FH
Gene descriptionⁱ Full gene name according to HGNC.	Fumarate hydratase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	27 NX
Kidney	40 NX
Liver	40 NX
Colon	9 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	18 NX
Skin	18 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	151 NX
Heart muscle	151 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	91 NX
Placenta	91 NX

Distal tubular cells	66 NX
Kidney	66 NX

Ductal cells	50 NX
Pancreas	50 NX

Early spermatids	161 NX
Testis	161 NX

Endothelial cells	18 NX
Heart muscle	30 NX
Placenta	25 NX
Eye	20 NX
Testis	20 NX
Lung	18 NX
Pancreas	18 NX
Liver	16 NX
Prostate	9 NX
Skin	9 NX

Enterocytes	46 NX
Small intestine	58 NX
Colon	41 NX
Rectum	31 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	22 NX
Heart muscle	47 NX
Placenta	42 NX
Lung	21 NX
Skin	14 NX
Prostate	11 NX

Glandular cells	16 NX
Prostate	16 NX

Granulocytes	19 NX
Lung	19 NX
Colon	18 NX

Hepatocytes	73 NX
Liver	73 NX

Hofbauer cells	45 NX
Placenta	45 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	17 NX
Colon	20 NX
Rectum	14 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	20 NX
Testis	20 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	27 NX
Pancreas	44 NX
Prostate	33 NX
Lung	32 NX
Kidney	27 NX
Testis	26 NX
Skin	16 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	30 NX
Pancreas	30 NX

Mucus-secreting cells	36 NX
Colon	45 NX
Rectum	35 NX
Small intestine	24 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	35 NX
Rectum	39 NX
Small intestine	35 NX
Colon	23 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	59 NX
Kidney	59 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	22 NX
Pancreas	64 NX
Heart muscle	35 NX
Prostate	22 NX
Skin	18 NX

Spermatocytes	83 NX
Testis	83 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	16 NX
Skin	16 NX

Syncytiotrophoblasts	139 NX
Placenta	139 NX

T-cells	13 NX
Kidney	22 NX
Liver	15 NX
Lung	13 NX
Colon	13 NX
Skin	12 NX
Prostate	9 NX

Undifferentiated cells	61 NX
Colon	88 NX
Small intestine	63 NX
Rectum	60 NX

Urothelial cells	16 NX
Prostate	16 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.