Cell type atlas - ITGA6 - The Human Protein Atlas

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ITGA6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITGA6
Gene descriptionⁱ Full gene name according to HGNC.	Integrin subunit alpha 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes, Urothelial cells, Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Urothelial cells, Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	8 NX
Kidney	9 NX
Liver	9 NX
Colon	6 NX

Basal glandular cells	171 NX
Prostate	171 NX

Basal keratinocytes	217 NX
Skin	217 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	28 NX
Heart muscle	28 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	4 NX
Lung	4 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	53 NX
Eye	53 NX

Cytotrophoblasts	80 NX
Placenta	80 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	29 NX
Testis	29 NX

Endothelial cells	130 NX
Heart muscle	362 NX
Skin	163 NX
Eye	156 NX
Lung	146 NX
Testis	130 NX
Prostate	91 NX
Placenta	58 NX
Pancreas	36 NX
Liver	2 NX

Enterocytes	79 NX
Colon	152 NX
Rectum	78 NX
Small intestine	50 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	53 NX
Pancreas	53 NX

Extravillous trophoblasts	27 NX
Placenta	27 NX

Fibroblasts	15 NX
Lung	75 NX
Heart muscle	20 NX
Prostate	19 NX
Skin	14 NX
Placenta	4 NX

Glandular cells	164 NX
Prostate	164 NX

Granulocytes	8 NX
Colon	9 NX
Lung	7 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	55 NX
Colon	68 NX
Rectum	42 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	2 NX
Liver	2 NX

Late spermatids	34 NX
Testis	34 NX

Leydig cells	4 NX
Testis	4 NX

Macrophages	9 NX
Prostate	22 NX
Skin	13 NX
Kidney	11 NX
Lung	11 NX
Testis	3 NX
Pancreas	0 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	103 NX
Colon	152 NX
Rectum	102 NX
Small intestine	80 NX

Muller glia cells	2 NX
Eye	2 NX

Pancreatic endocrine cells	86 NX
Pancreas	86 NX

Paneth cells	65 NX
Colon	181 NX
Rectum	65 NX
Small intestine	32 NX

Peritubular cells	3 NX
Testis	3 NX

Proximal tubular cells	49 NX
Kidney	49 NX

Rod photoreceptor cells	13 NX
Eye	12 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	13 NX
Heart muscle	35 NX
Prostate	21 NX
Skin	12 NX
Pancreas	3 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	26 NX
Testis	26 NX

Suprabasal keratinocytes	73 NX
Skin	73 NX

Syncytiotrophoblasts	19 NX
Placenta	19 NX

T-cells	15 NX
Prostate	26 NX
Skin	19 NX
Lung	17 NX
Liver	13 NX
Kidney	10 NX
Colon	7 NX

Undifferentiated cells	95 NX
Colon	196 NX
Small intestine	118 NX
Rectum	86 NX

Urothelial cells	210 NX
Prostate	210 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.