Cell type atlas - AAMDC - The Human Protein Atlas

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AAMDC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AAMDC
Gene descriptionⁱ Full gene name according to HGNC.	Adipogenesis associated Mth938 domain containing
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CACO-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	13 NX
Kidney	27 NX
Colon	12 NX
Liver	7 NX

Basal glandular cells	70 NX
Prostate	70 NX

Basal keratinocytes	57 NX
Skin	57 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	104 NX
Heart muscle	104 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	44 NX
Lung	44 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	75 NX
Kidney	75 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	22 NX
Placenta	22 NX

Distal tubular cells	123 NX
Kidney	123 NX

Ductal cells	56 NX
Pancreas	56 NX

Early spermatids	47 NX
Testis	47 NX

Endothelial cells	50 NX
Skin	90 NX
Liver	88 NX
Testis	69 NX
Placenta	62 NX
Pancreas	50 NX
Prostate	41 NX
Lung	38 NX
Heart muscle	35 NX
Eye	29 NX

Enterocytes	92 NX
Small intestine	129 NX
Colon	69 NX
Rectum	55 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	64 NX
Pancreas	64 NX

Extravillous trophoblasts	38 NX
Placenta	38 NX

Fibroblasts	61 NX
Lung	79 NX
Skin	61 NX
Placenta	61 NX
Heart muscle	57 NX
Prostate	34 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	40 NX
Colon	46 NX
Lung	35 NX

Hepatocytes	95 NX
Liver	95 NX

Hofbauer cells	40 NX
Placenta	40 NX

Horizontal cells	11 NX
Eye	11 NX

Intestinal endocrine cells	22 NX
Colon	27 NX
Rectum	16 NX

Ito cells	94 NX
Liver	94 NX

Kupffer cells	31 NX
Liver	31 NX

Late spermatids	28 NX
Testis	28 NX

Leydig cells	63 NX
Testis	63 NX

Macrophages	29 NX
Kidney	42 NX
Skin	35 NX
Prostate	33 NX
Testis	26 NX
Lung	21 NX
Pancreas	16 NX

Melanocytes	79 NX
Skin	79 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	82 NX
Pancreas	82 NX

Mucus-secreting cells	49 NX
Rectum	50 NX
Small intestine	50 NX
Colon	33 NX

Muller glia cells	57 NX
Eye	57 NX

Pancreatic endocrine cells	62 NX
Pancreas	62 NX

Paneth cells	98 NX
Colon	173 NX
Small intestine	98 NX
Rectum	85 NX

Peritubular cells	61 NX
Testis	61 NX

Proximal tubular cells	134 NX
Kidney	134 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	60 NX
Skin	76 NX
Prostate	72 NX
Pancreas	54 NX
Heart muscle	41 NX

Spermatocytes	90 NX
Testis	90 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	88 NX
Skin	88 NX

Syncytiotrophoblasts	13 NX
Placenta	13 NX

T-cells	18 NX
Kidney	34 NX
Skin	29 NX
Prostate	22 NX
Colon	19 NX
Liver	15 NX
Lung	4 NX

Undifferentiated cells	57 NX
Rectum	62 NX
Small intestine	57 NX
Colon	47 NX

Urothelial cells	64 NX
Prostate	64 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.