Cell type atlas - DNM1L - The Human Protein Atlas

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DNM1L

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNM1L
Gene descriptionⁱ Full gene name according to HGNC.	Dynamin 1 like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	39 NX
Lung	38 NX

B-cells	29 NX
Colon	36 NX
Liver	29 NX
Kidney	18 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	72 NX
Eye	72 NX

Cardiomyocytes	70 NX
Heart muscle	70 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	124 NX
Eye	124 NX

Cytotrophoblasts	26 NX
Placenta	26 NX

Distal tubular cells	27 NX
Kidney	27 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	51 NX
Testis	51 NX

Endothelial cells	35 NX
Lung	58 NX
Heart muscle	55 NX
Eye	47 NX
Testis	41 NX
Prostate	37 NX
Placenta	28 NX
Skin	26 NX
Liver	25 NX
Pancreas	25 NX

Enterocytes	15 NX
Colon	24 NX
Rectum	19 NX
Small intestine	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	22 NX
Pancreas	22 NX

Extravillous trophoblasts	51 NX
Placenta	51 NX

Fibroblasts	26 NX
Heart muscle	69 NX
Lung	46 NX
Prostate	37 NX
Skin	26 NX
Placenta	23 NX

Glandular cells	27 NX
Prostate	27 NX

Granulocytes	50 NX
Colon	55 NX
Lung	44 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	119 NX
Eye	119 NX

Intestinal endocrine cells	29 NX
Colon	31 NX
Rectum	28 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	33 NX
Liver	33 NX

Late spermatids	59 NX
Testis	59 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	32 NX
Lung	50 NX
Pancreas	40 NX
Prostate	37 NX
Skin	27 NX
Kidney	27 NX
Testis	27 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	44 NX
Pancreas	44 NX

Mucus-secreting cells	19 NX
Colon	27 NX
Small intestine	20 NX
Rectum	17 NX

Muller glia cells	66 NX
Eye	66 NX

Pancreatic endocrine cells	35 NX
Pancreas	35 NX

Paneth cells	14 NX
Rectum	20 NX
Small intestine	14 NX
Colon	6 NX

Peritubular cells	29 NX
Testis	29 NX

Proximal tubular cells	20 NX
Kidney	20 NX

Rod photoreceptor cells	150 NX
Eye	150 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	37 NX
Heart muscle	126 NX
Prostate	39 NX
Pancreas	37 NX
Skin	28 NX

Spermatocytes	66 NX
Testis	66 NX

Spermatogonia	51 NX
Testis	51 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	30 NX
Placenta	30 NX

T-cells	28 NX
Lung	59 NX
Colon	40 NX
Prostate	35 NX
Liver	24 NX
Skin	21 NX
Kidney	16 NX

Undifferentiated cells	24 NX
Colon	38 NX
Rectum	24 NX
Small intestine	21 NX

Urothelial cells	32 NX
Prostate	32 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.