Cell type atlas - FTL - The Human Protein Atlas

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FTL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FTL
Gene descriptionⁱ Full gene name according to HGNC.	Ferritin light chain
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Kupffer cells, Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HHSteC, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells, Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	1045 NX
Lung	1045 NX

Alveolar cells type 2	3325 NX
Lung	3325 NX

B-cells	4264 NX
Kidney	5115 NX
Liver	4842 NX
Colon	1133 NX

Basal glandular cells	4805 NX
Prostate	4805 NX

Basal keratinocytes	2482 NX
Skin	2482 NX

Bipolar cells	469 NX
Eye	469 NX

Cardiomyocytes	679 NX
Heart muscle	679 NX

Cholangiocytes	4145 NX
Liver	4145 NX

Ciliated cells	770 NX
Lung	770 NX

Club cells	1043 NX
Lung	1043 NX

Collecting duct cells	1918 NX
Kidney	1918 NX

Cone photoreceptor cells	167 NX
Eye	167 NX

Cytotrophoblasts	816 NX
Placenta	816 NX

Distal tubular cells	9070 NX
Kidney	9070 NX

Ductal cells	3524 NX
Pancreas	3524 NX

Early spermatids	248 NX
Testis	248 NX

Endothelial cells	2246 NX
Prostate	30116 NX
Liver	7487 NX
Skin	4726 NX
Eye	2831 NX
Pancreas	2246 NX
Placenta	1979 NX
Testis	1264 NX
Lung	1228 NX
Heart muscle	1069 NX

Enterocytes	2735 NX
Small intestine	17310 NX
Rectum	2639 NX
Colon	1204 NX

Erythroid cells	2149 NX
Liver	2149 NX

Exocrine glandular cells	5209 NX
Pancreas	5209 NX

Extravillous trophoblasts	1017 NX
Placenta	1017 NX

Fibroblasts	4146 NX
Prostate	16749 NX
Skin	6691 NX
Heart muscle	2823 NX
Placenta	2543 NX
Lung	1450 NX

Glandular cells	6478 NX
Prostate	6478 NX

Granulocytes	2237 NX
Lung	3399 NX
Colon	1074 NX

Hepatocytes	16333 NX
Liver	16333 NX

Hofbauer cells	67926 NX
Placenta	67926 NX

Horizontal cells	504 NX
Eye	504 NX

Intestinal endocrine cells	1552 NX
Rectum	2029 NX
Colon	1074 NX

Ito cells	4087 NX
Liver	4087 NX

Kupffer cells	48068 NX
Liver	48068 NX

Late spermatids	879 NX
Testis	879 NX

Leydig cells	3867 NX
Testis	3867 NX

Macrophages	17107 NX
Pancreas	71080 NX
Prostate	61860 NX
Kidney	35292 NX
Skin	14529 NX
Testis	13823 NX
Lung	13451 NX

Melanocytes	4823 NX
Skin	4823 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23992 NX
Pancreas	23992 NX

Mucus-secreting cells	2117 NX
Small intestine	3236 NX
Rectum	2106 NX
Colon	1273 NX

Muller glia cells	1185 NX
Eye	1185 NX

Pancreatic endocrine cells	7873 NX
Pancreas	7873 NX

Paneth cells	3673 NX
Small intestine	9174 NX
Rectum	3673 NX
Colon	2565 NX

Peritubular cells	1890 NX
Testis	1890 NX

Proximal tubular cells	39652 NX
Kidney	39652 NX

Rod photoreceptor cells	497 NX
Eye	496 NX

Sertoli cells	1319 NX
Testis	1319 NX

Smooth muscle cells	4075 NX
Prostate	8188 NX
Pancreas	6464 NX
Skin	3810 NX
Heart muscle	1289 NX

Spermatocytes	56 NX
Testis	56 NX

Spermatogonia	328 NX
Testis	328 NX

Suprabasal keratinocytes	1946 NX
Skin	1946 NX

Syncytiotrophoblasts	1257 NX
Placenta	1257 NX

T-cells	2297 NX
Prostate	8141 NX
Kidney	4585 NX
Skin	3054 NX
Liver	2229 NX
Lung	2140 NX
Colon	935 NX

Undifferentiated cells	2289 NX
Small intestine	3874 NX
Rectum	2289 NX
Colon	1369 NX

Urothelial cells	7488 NX
Prostate	7488 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.