Cell type atlas - EIF2AK1 - The Human Protein Atlas

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EIF2AK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2AK1
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2 alpha kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	43 NX
Lung	43 NX

B-cells	45 NX
Liver	53 NX
Colon	39 NX
Kidney	27 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	45 NX
Heart muscle	45 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	181 NX
Placenta	181 NX

Distal tubular cells	56 NX
Kidney	56 NX

Ductal cells	48 NX
Pancreas	48 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	22 NX
Pancreas	43 NX
Placenta	33 NX
Testis	31 NX
Eye	25 NX
Liver	22 NX
Heart muscle	21 NX
Lung	20 NX
Skin	18 NX
Prostate	17 NX

Enterocytes	43 NX
Rectum	56 NX
Colon	43 NX
Small intestine	42 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	64 NX
Placenta	64 NX

Fibroblasts	22 NX
Placenta	43 NX
Lung	37 NX
Skin	20 NX
Prostate	19 NX
Heart muscle	16 NX

Glandular cells	38 NX
Prostate	38 NX

Granulocytes	20 NX
Lung	30 NX
Colon	9 NX

Hepatocytes	56 NX
Liver	56 NX

Hofbauer cells	47 NX
Placenta	47 NX

Horizontal cells	30 NX
Eye	30 NX

Intestinal endocrine cells	37 NX
Rectum	47 NX
Colon	27 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	32 NX
Testis	32 NX

Macrophages	31 NX
Testis	42 NX
Prostate	41 NX
Lung	33 NX
Skin	29 NX
Kidney	29 NX
Pancreas	28 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	60 NX
Pancreas	60 NX

Mucus-secreting cells	60 NX
Rectum	71 NX
Colon	61 NX
Small intestine	54 NX

Muller glia cells	40 NX
Eye	40 NX

Pancreatic endocrine cells	47 NX
Pancreas	47 NX

Paneth cells	35 NX
Rectum	58 NX
Colon	35 NX
Small intestine	35 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	52 NX
Kidney	52 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	17 NX
Pancreas	43 NX
Heart muscle	34 NX
Skin	16 NX
Prostate	16 NX

Spermatocytes	33 NX
Testis	33 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	20 NX
Skin	20 NX

Syncytiotrophoblasts	310 NX
Placenta	310 NX

T-cells	35 NX
Liver	38 NX
Kidney	37 NX
Colon	35 NX
Lung	30 NX
Skin	26 NX
Prostate	22 NX

Undifferentiated cells	47 NX
Rectum	53 NX
Small intestine	47 NX
Colon	43 NX

Urothelial cells	26 NX
Prostate	26 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.