Cell type atlas - ZMPSTE24 - The Human Protein Atlas

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ZMPSTE24

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZMPSTE24
Gene descriptionⁱ Full gene name according to HGNC.	Zinc metallopeptidase STE24
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	24 NX
Lung	24 NX

B-cells	17 NX
Kidney	27 NX
Liver	14 NX
Colon	7 NX

Basal glandular cells	20 NX
Prostate	20 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	6 NX
Eye	6 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	50 NX
Lung	50 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	70 NX
Kidney	70 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	33 NX
Placenta	33 NX

Distal tubular cells	27 NX
Kidney	27 NX

Ductal cells	48 NX
Pancreas	48 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	32 NX
Heart muscle	48 NX
Pancreas	39 NX
Placenta	34 NX
Liver	32 NX
Lung	32 NX
Eye	22 NX
Skin	22 NX
Prostate	22 NX
Testis	17 NX

Enterocytes	34 NX
Rectum	47 NX
Colon	34 NX
Small intestine	30 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	32 NX
Placenta	32 NX

Fibroblasts	28 NX
Heart muscle	40 NX
Lung	31 NX
Skin	31 NX
Placenta	27 NX
Prostate	16 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	21 NX
Colon	28 NX
Lung	14 NX

Hepatocytes	57 NX
Liver	57 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	27 NX
Colon	27 NX
Rectum	26 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	30 NX
Lung	50 NX
Pancreas	37 NX
Kidney	31 NX
Skin	25 NX
Testis	23 NX
Prostate	16 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	32 NX
Pancreas	32 NX

Mucus-secreting cells	26 NX
Colon	32 NX
Rectum	27 NX
Small intestine	21 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	26 NX
Rectum	29 NX
Colon	26 NX
Small intestine	25 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	34 NX
Kidney	34 NX

Rod photoreceptor cells	6 NX
Eye	6 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	22 NX
Heart muscle	66 NX
Pancreas	46 NX
Prostate	22 NX
Skin	18 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	18 NX
Lung	37 NX
Kidney	24 NX
Colon	21 NX
Skin	21 NX
Liver	13 NX
Prostate	9 NX

Undifferentiated cells	28 NX
Colon	42 NX
Rectum	28 NX
Small intestine	23 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.