Cell type atlas - HSP90AA1 - The Human Protein Atlas

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HSP90AA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSP90AA1
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock protein 90 alpha family class A member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal glandular cells, Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal glandular cells, Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	1057 NX
Lung	1057 NX

Alveolar cells type 2	643 NX
Lung	643 NX

B-cells	718 NX
Kidney	749 NX
Colon	688 NX
Liver	642 NX

Basal glandular cells	6916 NX
Prostate	6916 NX

Basal keratinocytes	1191 NX
Skin	1191 NX

Bipolar cells	1040 NX
Eye	1040 NX

Cardiomyocytes	2043 NX
Heart muscle	2043 NX

Cholangiocytes	678 NX
Liver	678 NX

Ciliated cells	2974 NX
Lung	2974 NX

Club cells	1019 NX
Lung	1019 NX

Collecting duct cells	487 NX
Kidney	487 NX

Cone photoreceptor cells	1981 NX
Eye	1981 NX

Cytotrophoblasts	1153 NX
Placenta	1153 NX

Distal tubular cells	290 NX
Kidney	290 NX

Ductal cells	998 NX
Pancreas	998 NX

Early spermatids	320 NX
Testis	320 NX

Endothelial cells	819 NX
Prostate	2813 NX
Eye	1616 NX
Skin	1059 NX
Heart muscle	1018 NX
Pancreas	763 NX
Testis	697 NX
Placenta	603 NX
Lung	508 NX
Liver	303 NX

Enterocytes	646 NX
Colon	1219 NX
Small intestine	492 NX
Rectum	371 NX

Erythroid cells	935 NX
Liver	935 NX

Exocrine glandular cells	750 NX
Pancreas	750 NX

Extravillous trophoblasts	1610 NX
Placenta	1610 NX

Fibroblasts	1217 NX
Prostate	5826 NX
Lung	1548 NX
Skin	1255 NX
Heart muscle	1217 NX
Placenta	705 NX

Glandular cells	2797 NX
Prostate	2797 NX

Granulocytes	903 NX
Colon	1111 NX
Lung	695 NX

Hepatocytes	527 NX
Liver	527 NX

Hofbauer cells	1189 NX
Placenta	1189 NX

Horizontal cells	683 NX
Eye	683 NX

Intestinal endocrine cells	909 NX
Colon	1206 NX
Rectum	611 NX

Ito cells	339 NX
Liver	339 NX

Kupffer cells	569 NX
Liver	569 NX

Late spermatids	290 NX
Testis	290 NX

Leydig cells	678 NX
Testis	678 NX

Macrophages	1579 NX
Prostate	14281 NX
Skin	2658 NX
Testis	1967 NX
Lung	964 NX
Kidney	915 NX
Pancreas	721 NX

Melanocytes	1233 NX
Skin	1233 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	998 NX
Pancreas	998 NX

Mucus-secreting cells	507 NX
Colon	1551 NX
Small intestine	533 NX
Rectum	492 NX

Muller glia cells	1212 NX
Eye	1212 NX

Pancreatic endocrine cells	739 NX
Pancreas	739 NX

Paneth cells	659 NX
Colon	1572 NX
Small intestine	659 NX
Rectum	508 NX

Peritubular cells	680 NX
Testis	680 NX

Proximal tubular cells	610 NX
Kidney	610 NX

Rod photoreceptor cells	3288 NX
Eye	3288 NX

Sertoli cells	608 NX
Testis	608 NX

Smooth muscle cells	1394 NX
Prostate	5861 NX
Heart muscle	1467 NX
Skin	1261 NX
Pancreas	893 NX

Spermatocytes	3574 NX
Testis	3574 NX

Spermatogonia	1882 NX
Testis	1882 NX

Suprabasal keratinocytes	974 NX
Skin	974 NX

Syncytiotrophoblasts	1715 NX
Placenta	1715 NX

T-cells	761 NX
Prostate	30735 NX
Skin	1379 NX
Kidney	964 NX
Colon	883 NX
Liver	605 NX
Lung	490 NX

Undifferentiated cells	694 NX
Colon	1272 NX
Small intestine	714 NX
Rectum	522 NX

Urothelial cells	5558 NX
Prostate	5558 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.