Cell type atlas - EPB41L2 - The Human Protein Atlas

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EPB41L2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPB41L2
Gene descriptionⁱ Full gene name according to HGNC.	Erythrocyte membrane protein band 4.1 like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	25

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, Muller glia cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Muller glia cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	12 NX
Lung	12 NX

B-cells	15 NX
Colon	25 NX
Kidney	22 NX
Liver	4 NX

Basal glandular cells	12 NX
Prostate	12 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	53 NX
Eye	53 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	2 NX
Kidney	2 NX

Cone photoreceptor cells	212 NX
Eye	212 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	274 NX
Testis	274 NX

Endothelial cells	47 NX
Heart muscle	209 NX
Lung	166 NX
Eye	141 NX
Skin	62 NX
Liver	47 NX
Pancreas	47 NX
Placenta	41 NX
Prostate	29 NX
Testis	29 NX

Enterocytes	32 NX
Colon	73 NX
Small intestine	25 NX
Rectum	24 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	5 NX
Placenta	5 NX

Fibroblasts	75 NX
Heart muscle	161 NX
Lung	85 NX
Placenta	79 NX
Skin	74 NX
Prostate	58 NX

Glandular cells	3 NX
Prostate	3 NX

Granulocytes	43 NX
Lung	49 NX
Colon	37 NX

Hepatocytes	3 NX
Liver	3 NX

Hofbauer cells	30 NX
Placenta	30 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	10 NX
Colon	10 NX
Rectum	9 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	105 NX
Liver	105 NX

Late spermatids	245 NX
Testis	245 NX

Leydig cells	68 NX
Testis	68 NX

Macrophages	61 NX
Testis	85 NX
Prostate	84 NX
Skin	61 NX
Lung	47 NX
Kidney	22 NX
Pancreas	16 NX

Melanocytes	10 NX
Skin	10 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	17 NX
Pancreas	17 NX

Mucus-secreting cells	37 NX
Colon	47 NX
Small intestine	44 NX
Rectum	22 NX

Muller glia cells	500 NX
Eye	500 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	21 NX
Colon	32 NX
Small intestine	21 NX
Rectum	15 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	1332 NX
Eye	1332 NX

Sertoli cells	116 NX
Testis	116 NX

Smooth muscle cells	57 NX
Heart muscle	156 NX
Prostate	57 NX
Skin	53 NX
Pancreas	28 NX

Spermatocytes	54 NX
Testis	54 NX

Spermatogonia	80 NX
Testis	80 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	5 NX
Lung	16 NX
Prostate	13 NX
Colon	12 NX
Skin	10 NX
Liver	3 NX
Kidney	2 NX

Undifferentiated cells	22 NX
Small intestine	42 NX
Colon	30 NX
Rectum	12 NX

Urothelial cells	7 NX
Prostate	7 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.