Cell type atlas - SAR1A - The Human Protein Atlas

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SAR1A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SAR1A
Gene descriptionⁱ Full gene name according to HGNC.	Secretion associated Ras related GTPase 1A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	119 NX
Lung	119 NX

Alveolar cells type 2	114 NX
Lung	114 NX

B-cells	49 NX
Liver	70 NX
Colon	63 NX
Kidney	36 NX

Basal glandular cells	120 NX
Prostate	120 NX

Basal keratinocytes	209 NX
Skin	209 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	68 NX
Heart muscle	68 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	42 NX
Lung	42 NX

Club cells	65 NX
Lung	65 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	110 NX
Placenta	110 NX

Distal tubular cells	46 NX
Kidney	46 NX

Ductal cells	67 NX
Pancreas	67 NX

Early spermatids	3 NX
Testis	2 NX

Endothelial cells	99 NX
Skin	143 NX
Pancreas	129 NX
Prostate	118 NX
Lung	99 NX
Heart muscle	81 NX
Placenta	70 NX
Liver	63 NX
Eye	47 NX
Testis	45 NX

Enterocytes	49 NX
Small intestine	51 NX
Colon	49 NX
Rectum	45 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	68 NX
Pancreas	67 NX

Extravillous trophoblasts	162 NX
Placenta	162 NX

Fibroblasts	172 NX
Skin	247 NX
Prostate	172 NX
Placenta	138 NX
Heart muscle	108 NX
Lung	68 NX

Glandular cells	112 NX
Prostate	112 NX

Granulocytes	52 NX
Colon	55 NX
Lung	49 NX

Hepatocytes	103 NX
Liver	103 NX

Hofbauer cells	91 NX
Placenta	91 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	41 NX
Rectum	52 NX
Colon	31 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	48 NX
Liver	48 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	51 NX
Testis	51 NX

Macrophages	91 NX
Skin	147 NX
Prostate	98 NX
Lung	95 NX
Pancreas	87 NX
Kidney	71 NX
Testis	31 NX

Melanocytes	108 NX
Skin	108 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	66 NX
Pancreas	66 NX

Mucus-secreting cells	47 NX
Colon	101 NX
Rectum	45 NX
Small intestine	44 NX

Muller glia cells	57 NX
Eye	57 NX

Pancreatic endocrine cells	62 NX
Pancreas	62 NX

Paneth cells	52 NX
Small intestine	67 NX
Rectum	52 NX
Colon	35 NX

Peritubular cells	55 NX
Testis	55 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	31 NX
Eye	31 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	130 NX
Pancreas	172 NX
Prostate	130 NX
Skin	126 NX
Heart muscle	98 NX

Spermatocytes	54 NX
Testis	54 NX

Spermatogonia	49 NX
Testis	49 NX

Suprabasal keratinocytes	217 NX
Skin	217 NX

Syncytiotrophoblasts	200 NX
Placenta	200 NX

T-cells	95 NX
Skin	172 NX
Prostate	131 NX
Lung	95 NX
Liver	93 NX
Kidney	82 NX
Colon	74 NX

Undifferentiated cells	48 NX
Colon	53 NX
Rectum	48 NX
Small intestine	37 NX

Urothelial cells	134 NX
Prostate	134 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.