Cell type atlas - LXN - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LXN

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LXN
Gene descriptionⁱ Full gene name according to HGNC.	Latexin
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ciliated cells, granulocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ciliated cells, granulocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	8 NX
Kidney	9 NX
Liver	7 NX
Colon	6 NX

Basal glandular cells	62 NX
Prostate	62 NX

Basal keratinocytes	5 NX
Skin	5 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	3 NX
Heart muscle	3 NX

Cholangiocytes	3 NX
Liver	3 NX

Ciliated cells	130 NX
Lung	130 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	12 NX
Placenta	12 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	15 NX
Pancreas	15 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	29 NX
Pancreas	365 NX
Liver	223 NX
Placenta	98 NX
Heart muscle	32 NX
Prostate	30 NX
Eye	29 NX
Lung	26 NX
Skin	19 NX
Testis	19 NX

Enterocytes	33 NX
Small intestine	40 NX
Rectum	38 NX
Colon	21 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	24 NX
Pancreas	24 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	20 NX
Lung	84 NX
Heart muscle	34 NX
Placenta	31 NX
Prostate	20 NX
Skin	3 NX

Glandular cells	30 NX
Prostate	30 NX

Granulocytes	114 NX
Lung	219 NX
Colon	9 NX

Hepatocytes	0 NX
Liver	0 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	34 NX
Colon	51 NX
Rectum	16 NX

Ito cells	49 NX
Liver	49 NX

Kupffer cells	4 NX
Liver	4 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	8 NX
Testis	8 NX

Macrophages	14 NX
Lung	18 NX
Skin	16 NX
Pancreas	16 NX
Prostate	11 NX
Testis	6 NX
Kidney	3 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	63 NX
Colon	75 NX
Rectum	67 NX
Small intestine	54 NX

Muller glia cells	8 NX
Eye	8 NX

Pancreatic endocrine cells	13 NX
Pancreas	13 NX

Paneth cells	69 NX
Rectum	74 NX
Colon	69 NX
Small intestine	14 NX

Peritubular cells	3 NX
Testis	3 NX

Proximal tubular cells	12 NX
Kidney	12 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	4 NX
Pancreas	61 NX
Prostate	7 NX
Heart muscle	4 NX
Skin	0 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	7 NX
Skin	7 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	8 NX
Prostate	13 NX
Lung	9 NX
Kidney	8 NX
Liver	6 NX
Skin	6 NX
Colon	5 NX

Undifferentiated cells	26 NX
Rectum	47 NX
Small intestine	25 NX
Colon	12 NX

Urothelial cells	71 NX
Prostate	71 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.