Cell type atlas - SDF4 - The Human Protein Atlas

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SDF4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SDF4
Gene descriptionⁱ Full gene name according to HGNC.	Stromal cell derived factor 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	50 NX
Liver	93 NX
Colon	45 NX
Kidney	36 NX

Basal glandular cells	64 NX
Prostate	64 NX

Basal keratinocytes	107 NX
Skin	107 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	31 NX
Heart muscle	31 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	104 NX
Placenta	104 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	70 NX
Pancreas	70 NX

Early spermatids	29 NX
Testis	29 NX

Endothelial cells	70 NX
Skin	111 NX
Pancreas	86 NX
Liver	83 NX
Prostate	71 NX
Placenta	70 NX
Testis	70 NX
Eye	54 NX
Lung	29 NX
Heart muscle	25 NX

Enterocytes	256 NX
Small intestine	339 NX
Rectum	218 NX
Colon	207 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	62 NX
Pancreas	62 NX

Extravillous trophoblasts	265 NX
Placenta	265 NX

Fibroblasts	99 NX
Skin	141 NX
Placenta	97 NX
Prostate	91 NX
Heart muscle	37 NX
Lung	30 NX

Glandular cells	86 NX
Prostate	86 NX

Granulocytes	36 NX
Colon	46 NX
Lung	26 NX

Hepatocytes	98 NX
Liver	98 NX

Hofbauer cells	111 NX
Placenta	111 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	63 NX
Rectum	75 NX
Colon	51 NX

Ito cells	72 NX
Liver	72 NX

Kupffer cells	62 NX
Liver	62 NX

Late spermatids	26 NX
Testis	26 NX

Leydig cells	88 NX
Testis	88 NX

Macrophages	73 NX
Skin	124 NX
Pancreas	101 NX
Prostate	80 NX
Testis	66 NX
Kidney	53 NX
Lung	26 NX

Melanocytes	159 NX
Skin	159 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	50 NX
Pancreas	50 NX

Mucus-secreting cells	147 NX
Colon	175 NX
Small intestine	168 NX
Rectum	138 NX

Muller glia cells	56 NX
Eye	56 NX

Pancreatic endocrine cells	64 NX
Pancreas	64 NX

Paneth cells	189 NX
Colon	219 NX
Small intestine	189 NX
Rectum	170 NX

Peritubular cells	72 NX
Testis	72 NX

Proximal tubular cells	49 NX
Kidney	49 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	99 NX
Pancreas	119 NX
Skin	105 NX
Prostate	63 NX
Heart muscle	25 NX

Spermatocytes	77 NX
Testis	77 NX

Spermatogonia	65 NX
Testis	65 NX

Suprabasal keratinocytes	100 NX
Skin	100 NX

Syncytiotrophoblasts	141 NX
Placenta	141 NX

T-cells	71 NX
Skin	150 NX
Liver	74 NX
Colon	73 NX
Kidney	61 NX
Prostate	48 NX
Lung	30 NX

Undifferentiated cells	158 NX
Colon	166 NX
Rectum	158 NX
Small intestine	141 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.