Cell type atlas - NRDC - The Human Protein Atlas

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NRDC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NRDC
Gene descriptionⁱ Full gene name according to HGNC.	Nardilysin convertase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	56 NX
Lung	56 NX

B-cells	18 NX
Kidney	36 NX
Liver	35 NX
Colon	0 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	0 NX
Skin	0 NX

Bipolar cells	67 NX
Eye	67 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	108 NX
Lung	108 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	77 NX
Eye	77 NX

Cytotrophoblasts	47 NX
Placenta	47 NX

Distal tubular cells	27 NX
Kidney	27 NX

Ductal cells	38 NX
Pancreas	38 NX

Early spermatids	493 NX
Testis	493 NX

Endothelial cells	33 NX
Pancreas	57 NX
Testis	51 NX
Lung	47 NX
Eye	43 NX
Prostate	38 NX
Placenta	33 NX
Liver	20 NX
Heart muscle	0 NX
Skin	0 NX

Enterocytes	19 NX
Small intestine	24 NX
Rectum	21 NX
Colon	0 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	55 NX
Pancreas	55 NX

Extravillous trophoblasts	37 NX
Placenta	37 NX

Fibroblasts	34 NX
Lung	70 NX
Placenta	38 NX
Prostate	34 NX
Skin	0 NX
Heart muscle	0 NX

Glandular cells	42 NX
Prostate	42 NX

Granulocytes	33 NX
Lung	65 NX
Colon	0 NX

Hepatocytes	53 NX
Liver	53 NX

Hofbauer cells	40 NX
Placenta	40 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	18 NX
Rectum	35 NX
Colon	0 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	38 NX
Liver	38 NX

Late spermatids	1318 NX
Testis	1318 NX

Leydig cells	61 NX
Testis	61 NX

Macrophages	53 NX
Lung	123 NX
Pancreas	80 NX
Testis	59 NX
Kidney	48 NX
Prostate	45 NX
Skin	0 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	26 NX
Small intestine	30 NX
Rectum	29 NX
Colon	0 NX

Muller glia cells	53 NX
Eye	53 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	14 NX
Rectum	24 NX
Small intestine	14 NX
Colon	0 NX

Peritubular cells	56 NX
Testis	56 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	68 NX
Eye	68 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	0 NX
Pancreas	54 NX
Prostate	50 NX
Skin	0 NX
Heart muscle	0 NX

Spermatocytes	38 NX
Testis	38 NX

Spermatogonia	21 NX
Testis	21 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	69 NX
Placenta	69 NX

T-cells	41 NX
Lung	98 NX
Liver	45 NX
Kidney	42 NX
Prostate	18 NX
Colon	0 NX
Skin	0 NX

Undifferentiated cells	28 NX
Rectum	30 NX
Small intestine	29 NX
Colon	0 NX

Urothelial cells	33 NX
Prostate	33 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.