Cell type atlas - DYNC1I2 - The Human Protein Atlas

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DYNC1I2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DYNC1I2
Gene descriptionⁱ Full gene name according to HGNC.	Dynein cytoplasmic 1 intermediate chain 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	185 NX
Lung	185 NX

Alveolar cells type 2	56 NX
Lung	56 NX

B-cells	69 NX
Liver	79 NX
Colon	67 NX
Kidney	31 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	45 NX
Skin	45 NX

Bipolar cells	68 NX
Eye	68 NX

Cardiomyocytes	67 NX
Heart muscle	67 NX

Cholangiocytes	196 NX
Liver	196 NX

Ciliated cells	111 NX
Lung	111 NX

Club cells	97 NX
Lung	97 NX

Collecting duct cells	161 NX
Kidney	161 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	86 NX
Placenta	86 NX

Distal tubular cells	111 NX
Kidney	111 NX

Ductal cells	177 NX
Pancreas	177 NX

Early spermatids	59 NX
Testis	59 NX

Endothelial cells	119 NX
Pancreas	186 NX
Lung	184 NX
Liver	164 NX
Testis	125 NX
Eye	119 NX
Placenta	119 NX
Heart muscle	69 NX
Skin	67 NX
Prostate	54 NX

Enterocytes	140 NX
Colon	166 NX
Rectum	123 NX
Small intestine	119 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	140 NX
Pancreas	140 NX

Extravillous trophoblasts	89 NX
Placenta	89 NX

Fibroblasts	77 NX
Lung	139 NX
Placenta	133 NX
Heart muscle	77 NX
Skin	58 NX
Prostate	43 NX

Glandular cells	39 NX
Prostate	39 NX

Granulocytes	96 NX
Lung	156 NX
Colon	37 NX

Hepatocytes	131 NX
Liver	131 NX

Hofbauer cells	90 NX
Placenta	90 NX

Horizontal cells	76 NX
Eye	76 NX

Intestinal endocrine cells	81 NX
Colon	99 NX
Rectum	63 NX

Ito cells	188 NX
Liver	188 NX

Kupffer cells	142 NX
Liver	142 NX

Late spermatids	31 NX
Testis	31 NX

Leydig cells	119 NX
Testis	119 NX

Macrophages	95 NX
Testis	135 NX
Lung	133 NX
Kidney	101 NX
Pancreas	89 NX
Skin	43 NX
Prostate	35 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	152 NX
Pancreas	152 NX

Mucus-secreting cells	111 NX
Colon	157 NX
Rectum	111 NX
Small intestine	110 NX

Muller glia cells	91 NX
Eye	91 NX

Pancreatic endocrine cells	162 NX
Pancreas	161 NX

Paneth cells	107 NX
Colon	164 NX
Rectum	107 NX
Small intestine	70 NX

Peritubular cells	130 NX
Testis	130 NX

Proximal tubular cells	165 NX
Kidney	165 NX

Rod photoreceptor cells	120 NX
Eye	120 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	79 NX
Pancreas	153 NX
Heart muscle	88 NX
Skin	72 NX
Prostate	59 NX

Spermatocytes	210 NX
Testis	210 NX

Spermatogonia	93 NX
Testis	93 NX

Suprabasal keratinocytes	52 NX
Skin	52 NX

Syncytiotrophoblasts	97 NX
Placenta	97 NX

T-cells	52 NX
Kidney	70 NX
Lung	62 NX
Liver	58 NX
Colon	50 NX
Prostate	48 NX
Skin	33 NX

Undifferentiated cells	94 NX
Colon	132 NX
Small intestine	107 NX
Rectum	89 NX

Urothelial cells	47 NX
Prostate	47 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.