Cell type atlas - TOP2B - The Human Protein Atlas

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TOP2B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOP2B
Gene descriptionⁱ Full gene name according to HGNC.	DNA topoisomerase II beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (REH)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	58 NX
Lung	58 NX

B-cells	25 NX
Colon	42 NX
Liver	24 NX
Kidney	22 NX

Basal glandular cells	36 NX
Prostate	36 NX

Basal keratinocytes	35 NX
Skin	35 NX

Bipolar cells	54 NX
Eye	53 NX

Cardiomyocytes	109 NX
Heart muscle	109 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	53 NX
Eye	53 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	32 NX
Heart muscle	49 NX
Prostate	36 NX
Placenta	34 NX
Pancreas	32 NX
Lung	29 NX
Skin	29 NX
Eye	27 NX
Testis	27 NX
Liver	25 NX

Enterocytes	18 NX
Rectum	39 NX
Small intestine	20 NX
Colon	12 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	21 NX
Placenta	21 NX

Fibroblasts	35 NX
Lung	46 NX
Heart muscle	40 NX
Skin	36 NX
Prostate	35 NX
Placenta	31 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	31 NX
Lung	63 NX
Colon	0 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	23 NX
Placenta	23 NX

Horizontal cells	57 NX
Eye	57 NX

Intestinal endocrine cells	57 NX
Colon	58 NX
Rectum	56 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	39 NX
Skin	43 NX
Lung	40 NX
Kidney	38 NX
Testis	34 NX
Prostate	31 NX
Pancreas	16 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	22 NX
Pancreas	22 NX

Mucus-secreting cells	33 NX
Rectum	37 NX
Small intestine	29 NX
Colon	18 NX

Muller glia cells	46 NX
Eye	46 NX

Pancreatic endocrine cells	32 NX
Pancreas	32 NX

Paneth cells	18 NX
Rectum	34 NX
Small intestine	18 NX
Colon	9 NX

Peritubular cells	32 NX
Testis	32 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	89 NX
Eye	89 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	37 NX
Heart muscle	92 NX
Prostate	37 NX
Skin	35 NX
Pancreas	15 NX

Spermatocytes	66 NX
Testis	66 NX

Spermatogonia	27 NX
Testis	27 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	39 NX
Placenta	39 NX

T-cells	45 NX
Lung	59 NX
Liver	51 NX
Colon	45 NX
Prostate	44 NX
Kidney	37 NX
Skin	35 NX

Undifferentiated cells	38 NX
Rectum	42 NX
Small intestine	36 NX
Colon	24 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.