Cell type atlas - TPD52 - The Human Protein Atlas

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TPD52

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPD52
Gene descriptionⁱ Full gene name according to HGNC.	Tumor protein D52
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (memory B-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	109 NX
Kidney	111 NX
Colon	106 NX
Liver	88 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	72 NX
Skin	72 NX

Bipolar cells	178 NX
Eye	178 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	71 NX
Liver	71 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	42 NX
Lung	42 NX

Collecting duct cells	63 NX
Kidney	63 NX

Cone photoreceptor cells	112 NX
Eye	112 NX

Cytotrophoblasts	81 NX
Placenta	81 NX

Distal tubular cells	144 NX
Kidney	144 NX

Ductal cells	102 NX
Pancreas	102 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	20 NX
Eye	59 NX
Testis	53 NX
Skin	38 NX
Placenta	29 NX
Prostate	20 NX
Lung	18 NX
Heart muscle	10 NX
Liver	9 NX
Pancreas	0 NX

Enterocytes	163 NX
Rectum	202 NX
Colon	195 NX
Small intestine	100 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	70 NX
Pancreas	70 NX

Extravillous trophoblasts	107 NX
Placenta	107 NX

Fibroblasts	5 NX
Lung	24 NX
Prostate	9 NX
Skin	6 NX
Placenta	5 NX
Heart muscle	4 NX

Glandular cells	216 NX
Prostate	216 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	12 NX
Placenta	12 NX

Horizontal cells	30 NX
Eye	30 NX

Intestinal endocrine cells	163 NX
Colon	184 NX
Rectum	143 NX

Ito cells	7 NX
Liver	7 NX

Kupffer cells	10 NX
Liver	10 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	1 NX
Testis	1 NX

Macrophages	10 NX
Prostate	42 NX
Skin	22 NX
Lung	10 NX
Kidney	8 NX
Pancreas	5 NX
Testis	3 NX

Melanocytes	100 NX
Skin	100 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	155 NX
Pancreas	155 NX

Mucus-secreting cells	244 NX
Colon	429 NX
Rectum	275 NX
Small intestine	206 NX

Muller glia cells	35 NX
Eye	35 NX

Pancreatic endocrine cells	73 NX
Pancreas	73 NX

Paneth cells	283 NX
Small intestine	309 NX
Rectum	283 NX
Colon	271 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	103 NX
Kidney	103 NX

Rod photoreceptor cells	205 NX
Eye	204 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	9 NX
Heart muscle	11 NX
Prostate	10 NX
Pancreas	9 NX
Skin	6 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	109 NX
Skin	109 NX

Syncytiotrophoblasts	193 NX
Placenta	193 NX

T-cells	42 NX
Skin	94 NX
Prostate	87 NX
Colon	49 NX
Kidney	35 NX
Lung	33 NX
Liver	29 NX

Undifferentiated cells	175 NX
Colon	322 NX
Rectum	168 NX
Small intestine	162 NX

Urothelial cells	108 NX
Prostate	108 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.