Cell type atlas - SLC25A3 - The Human Protein Atlas

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SLC25A3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A3
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	200 NX
Lung	200 NX

Alveolar cells type 2	265 NX
Lung	265 NX

B-cells	295 NX
Liver	403 NX
Colon	358 NX
Kidney	232 NX

Basal glandular cells	455 NX
Prostate	455 NX

Basal keratinocytes	334 NX
Skin	334 NX

Bipolar cells	212 NX
Eye	212 NX

Cardiomyocytes	1402 NX
Heart muscle	1402 NX

Cholangiocytes	385 NX
Liver	385 NX

Ciliated cells	146 NX
Lung	146 NX

Club cells	192 NX
Lung	192 NX

Collecting duct cells	204 NX
Kidney	204 NX

Cone photoreceptor cells	75 NX
Eye	75 NX

Cytotrophoblasts	677 NX
Placenta	677 NX

Distal tubular cells	741 NX
Kidney	741 NX

Ductal cells	434 NX
Pancreas	434 NX

Early spermatids	32 NX
Testis	32 NX

Endothelial cells	273 NX
Prostate	512 NX
Placenta	416 NX
Pancreas	333 NX
Testis	298 NX
Heart muscle	286 NX
Liver	263 NX
Skin	259 NX
Eye	242 NX
Lung	160 NX

Enterocytes	744 NX
Small intestine	805 NX
Rectum	678 NX
Colon	551 NX

Erythroid cells	164 NX
Liver	164 NX

Exocrine glandular cells	762 NX
Pancreas	762 NX

Extravillous trophoblasts	756 NX
Placenta	756 NX

Fibroblasts	401 NX
Placenta	546 NX
Prostate	510 NX
Heart muscle	401 NX
Skin	265 NX
Lung	203 NX

Glandular cells	371 NX
Prostate	371 NX

Granulocytes	206 NX
Colon	220 NX
Lung	191 NX

Hepatocytes	374 NX
Liver	374 NX

Hofbauer cells	527 NX
Placenta	527 NX

Horizontal cells	277 NX
Eye	277 NX

Intestinal endocrine cells	300 NX
Rectum	311 NX
Colon	289 NX

Ito cells	249 NX
Liver	249 NX

Kupffer cells	431 NX
Liver	431 NX

Late spermatids	20 NX
Testis	19 NX

Leydig cells	236 NX
Testis	236 NX

Macrophages	288 NX
Prostate	589 NX
Pancreas	393 NX
Kidney	377 NX
Testis	314 NX
Lung	243 NX
Skin	218 NX

Melanocytes	415 NX
Skin	415 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	544 NX
Pancreas	544 NX

Mucus-secreting cells	392 NX
Colon	518 NX
Rectum	385 NX
Small intestine	312 NX

Muller glia cells	226 NX
Eye	226 NX

Pancreatic endocrine cells	536 NX
Pancreas	536 NX

Paneth cells	501 NX
Colon	677 NX
Rectum	501 NX
Small intestine	449 NX

Peritubular cells	241 NX
Testis	241 NX

Proximal tubular cells	802 NX
Kidney	802 NX

Rod photoreceptor cells	176 NX
Eye	176 NX

Sertoli cells	298 NX
Testis	298 NX

Smooth muscle cells	388 NX
Prostate	604 NX
Pancreas	576 NX
Heart muscle	379 NX
Skin	346 NX

Spermatocytes	94 NX
Testis	94 NX

Spermatogonia	178 NX
Testis	178 NX

Suprabasal keratinocytes	317 NX
Skin	317 NX

Syncytiotrophoblasts	681 NX
Placenta	681 NX

T-cells	270 NX
Prostate	536 NX
Colon	314 NX
Liver	300 NX
Kidney	270 NX
Skin	252 NX
Lung	190 NX

Undifferentiated cells	621 NX
Rectum	643 NX
Small intestine	621 NX
Colon	608 NX

Urothelial cells	559 NX
Prostate	559 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.