Cell type atlas - MARK3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MARK3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MARK3
Gene descriptionⁱ Full gene name according to HGNC.	Microtubule affinity regulating kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	64 NX
Lung	64 NX

B-cells	40 NX
Colon	45 NX
Kidney	36 NX
Liver	26 NX

Basal glandular cells	44 NX
Prostate	44 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	70 NX
Eye	70 NX

Cardiomyocytes	70 NX
Heart muscle	70 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	52 NX
Lung	52 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	153 NX
Eye	153 NX

Cytotrophoblasts	27 NX
Placenta	27 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	40 NX
Pancreas	40 NX

Early spermatids	27 NX
Testis	27 NX

Endothelial cells	50 NX
Liver	79 NX
Heart muscle	77 NX
Prostate	63 NX
Testis	57 NX
Pancreas	50 NX
Eye	43 NX
Placenta	32 NX
Skin	30 NX
Lung	26 NX

Enterocytes	30 NX
Colon	35 NX
Rectum	32 NX
Small intestine	30 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	26 NX
Placenta	26 NX

Fibroblasts	43 NX
Heart muscle	69 NX
Lung	67 NX
Prostate	51 NX
Skin	43 NX
Placenta	33 NX

Glandular cells	54 NX
Prostate	54 NX

Granulocytes	47 NX
Colon	55 NX
Lung	40 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	26 NX
Placenta	26 NX

Horizontal cells	56 NX
Eye	56 NX

Intestinal endocrine cells	30 NX
Rectum	33 NX
Colon	27 NX

Ito cells	47 NX
Liver	47 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	38 NX
Testis	38 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	44 NX
Prostate	54 NX
Skin	53 NX
Lung	46 NX
Kidney	39 NX
Testis	37 NX
Pancreas	23 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	51 NX
Pancreas	51 NX

Mucus-secreting cells	29 NX
Rectum	35 NX
Colon	29 NX
Small intestine	23 NX

Muller glia cells	36 NX
Eye	36 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	29 NX
Colon	35 NX
Rectum	29 NX
Small intestine	28 NX

Peritubular cells	56 NX
Testis	56 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	91 NX
Eye	91 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	44 NX
Heart muscle	66 NX
Prostate	45 NX
Pancreas	44 NX
Skin	33 NX

Spermatocytes	40 NX
Testis	40 NX

Spermatogonia	56 NX
Testis	56 NX

Suprabasal keratinocytes	46 NX
Skin	46 NX

Syncytiotrophoblasts	41 NX
Placenta	41 NX

T-cells	43 NX
Prostate	61 NX
Colon	60 NX
Kidney	50 NX
Skin	46 NX
Lung	33 NX
Liver	33 NX

Undifferentiated cells	28 NX
Rectum	32 NX
Small intestine	28 NX
Colon	25 NX

Urothelial cells	99 NX
Prostate	99 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.