Cell type atlas - KDM5A - The Human Protein Atlas

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KDM5A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KDM5A
Gene descriptionⁱ Full gene name according to HGNC.	Lysine demethylase 5A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	54 NX
Lung	54 NX

B-cells	58 NX
Colon	69 NX
Kidney	58 NX
Liver	43 NX

Basal glandular cells	20 NX
Prostate	20 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	64 NX
Eye	64 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	40 NX
Lung	40 NX

Club cells	40 NX
Lung	40 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	110 NX
Eye	110 NX

Cytotrophoblasts	38 NX
Placenta	38 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	79 NX
Testis	79 NX

Endothelial cells	47 NX
Eye	61 NX
Heart muscle	53 NX
Liver	49 NX
Testis	47 NX
Pancreas	47 NX
Placenta	38 NX
Prostate	32 NX
Lung	32 NX
Skin	26 NX

Enterocytes	34 NX
Rectum	51 NX
Colon	43 NX
Small intestine	32 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	27 NX
Pancreas	27 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	36 NX
Lung	64 NX
Placenta	39 NX
Heart muscle	36 NX
Prostate	34 NX
Skin	33 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	52 NX
Lung	67 NX
Colon	37 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	83 NX
Eye	83 NX

Intestinal endocrine cells	67 NX
Colon	99 NX
Rectum	35 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	53 NX
Liver	53 NX

Late spermatids	21 NX
Testis	21 NX

Leydig cells	45 NX
Testis	45 NX

Macrophages	47 NX
Testis	74 NX
Lung	66 NX
Kidney	52 NX
Prostate	42 NX
Skin	35 NX
Pancreas	28 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	36 NX
Rectum	38 NX
Colon	36 NX
Small intestine	32 NX

Muller glia cells	48 NX
Eye	48 NX

Pancreatic endocrine cells	31 NX
Pancreas	31 NX

Paneth cells	38 NX
Small intestine	49 NX
Rectum	38 NX
Colon	14 NX

Peritubular cells	52 NX
Testis	52 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	69 NX
Eye	69 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	31 NX
Heart muscle	93 NX
Prostate	37 NX
Skin	27 NX
Pancreas	26 NX

Spermatocytes	106 NX
Testis	106 NX

Spermatogonia	112 NX
Testis	112 NX

Suprabasal keratinocytes	42 NX
Skin	42 NX

Syncytiotrophoblasts	60 NX
Placenta	60 NX

T-cells	63 NX
Liver	71 NX
Colon	65 NX
Kidney	63 NX
Lung	62 NX
Skin	53 NX
Prostate	31 NX

Undifferentiated cells	36 NX
Rectum	39 NX
Colon	35 NX
Small intestine	32 NX

Urothelial cells	34 NX
Prostate	34 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.