FCGR2B protein expression summary - The Human Protein Atlas

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FCGR2B

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Fc fragment of IgG receptor IIb
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FCGR2B (CD32, CD32B, FCG2, FCGR2)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Group enriched (blood, placenta)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Ito cells, Macrophages)
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil, memory B-cell)
Cancer prognostic summary	Prognostic marker in renal cancer (unfavorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	IgG-binding protein, Receptor
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Host-virus interaction
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes, FDA approved drug targets, Proto-oncogene, Systemic lupus erythematosus
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]... show less

TISSUE ATLASⁱ Summary of data presented in the Tissue Atlas and representative images of protein expression (left) and mRNA expression (right). The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Group enriched (blood, placenta)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Cytoplasmic expression in endothelial cells in placenta and subsets of lymphoid cells.

SINGLE CELL TYPE ATLASⁱ Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e.g. epithelial cells and germ cells. The image is clickable and will redirect to more Cell Type Atlas data. The Cell Type Atlas contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Ito cells, Macrophages)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Daudi, HMC-1, NB-4, RPMI-8226)

PATHOLOGY ATLASⁱ Summary of data presented in the Pathology Atlas , with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology Atlas data. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
	Renal cancer p<0.001
Prognostic summary	Prognostic marker in renal cancer (unfavorable)
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in many

No regional specificity can be calculated, but other data exist for this gene

BLOOD ATLASⁱ Summary of data presented in the Blood Atlas and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more Blood Atlas data. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e.g. B-cells and granulocytes. Analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) and proteins detected in human blood are also presented. Read more

Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (basophil, memory B-cell)
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Not available
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	NA

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	FCGR2B (HGNC Symbol)
Synonyms	CD32, CD32B, FCG2, FCGR2
Description	Fc fragment of IgG receptor IIb (HGNC Symbol)
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161663147 - 161678654
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes FDA approved drug targets
Ensembl	ENSG00000072694 (version 92.38)
Entrez gene	2213
UniProt	P31994 (UniProt - Evidence at protein level)
neXtProt	NX_P31994
Antibodypedia	FCGR2B antibodies

PROTEIN BROWSERⁱ

FCGR2B-201

FCGR2B-202

FCGR2B-203

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR2B-201 ENSP00000236937 ENST00000236937	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001540 [amyloid-beta binding] GO:0001811 [negative regulation of type I hypersensitivity] GO:0001814 [negative regulation of antibody-dependent cellular cytotoxicity] GO:0002266 [follicular dendritic cell activation] GO:0002313 [mature B cell differentiation involved in immune response] GO:0002316 [follicular B cell differentiation] GO:0002436 [immune complex clearance by monocytes and macrophages] GO:0002605 [negative regulation of dendritic cell antigen processing and presentation] GO:0002622 [regulation of B cell antigen processing and presentation] GO:0002638 [negative regulation of immunoglobulin production] GO:0002819 [regulation of adaptive immune response] GO:0002865 [negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922 [positive regulation of humoral immune response] GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006911 [phagocytosis, engulfment] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0009617 [response to bacterium] GO:0009897 [external side of plasma membrane] GO:0010469 [regulation of receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016064 [immunoglobulin mediated immune response] GO:0019772 [low-affinity IgG receptor activity] GO:0019864 [IgG binding] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549 [cerebellum development] GO:0030889 [negative regulation of B cell proliferation] GO:0032693 [negative regulation of interleukin-10 production] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031 [negative regulation of macrophage activation] GO:0043197 [dendritic spine] GO:0043318 [negative regulation of cytotoxic T cell degranulation] GO:0044297 [cell body] GO:0044877 [macromolecular complex binding] GO:0045088 [regulation of innate immune response] GO:0046330 [positive regulation of JNK cascade] GO:0050710 [negative regulation of cytokine secretion] GO:0050765 [negative regulation of phagocytosis] GO:0050766 [positive regulation of phagocytosis] GO:0050776 [regulation of immune response] GO:0050777 [negative regulation of immune response] GO:0050869 [negative regulation of B cell activation] GO:0071219 [cellular response to molecule of bacterial origin] GO:0090264 [regulation of immune complex clearance by monocytes and macrophages] GO:1901216 [positive regulation of neuron death] GO:1902564 [negative regulation of neutrophil activation] GO:1902950 [regulation of dendritic spine maintenance] GO:1904646 [cellular response to amyloid-beta] GO:1905898 [positive regulation of response to endoplasmic reticulum stress] GO:2001199 [negative regulation of dendritic cell differentiation] Show all	291 aa 31.9 kDa	Yes	1
FCGR2B-202 ENSP00000351497 ENST00000358671	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001540 [amyloid-beta binding] GO:0001811 [negative regulation of type I hypersensitivity] GO:0001814 [negative regulation of antibody-dependent cellular cytotoxicity] GO:0002266 [follicular dendritic cell activation] GO:0002313 [mature B cell differentiation involved in immune response] GO:0002316 [follicular B cell differentiation] GO:0002436 [immune complex clearance by monocytes and macrophages] GO:0002605 [negative regulation of dendritic cell antigen processing and presentation] GO:0002622 [regulation of B cell antigen processing and presentation] GO:0002638 [negative regulation of immunoglobulin production] GO:0002819 [regulation of adaptive immune response] GO:0002865 [negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922 [positive regulation of humoral immune response] GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006911 [phagocytosis, engulfment] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0009617 [response to bacterium] GO:0009897 [external side of plasma membrane] GO:0010469 [regulation of receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016064 [immunoglobulin mediated immune response] GO:0019772 [low-affinity IgG receptor activity] GO:0019864 [IgG binding] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549 [cerebellum development] GO:0030889 [negative regulation of B cell proliferation] GO:0032693 [negative regulation of interleukin-10 production] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031 [negative regulation of macrophage activation] GO:0043197 [dendritic spine] GO:0043318 [negative regulation of cytotoxic T cell degranulation] GO:0044297 [cell body] GO:0044877 [macromolecular complex binding] GO:0045088 [regulation of innate immune response] GO:0046330 [positive regulation of JNK cascade] GO:0050710 [negative regulation of cytokine secretion] GO:0050765 [negative regulation of phagocytosis] GO:0050766 [positive regulation of phagocytosis] GO:0050776 [regulation of immune response] GO:0050777 [negative regulation of immune response] GO:0050869 [negative regulation of B cell activation] GO:0071219 [cellular response to molecule of bacterial origin] GO:0090264 [regulation of immune complex clearance by monocytes and macrophages] GO:1901216 [positive regulation of neuron death] GO:1902564 [negative regulation of neutrophil activation] GO:1902950 [regulation of dendritic spine maintenance] GO:1904646 [cellular response to amyloid-beta] GO:1905898 [positive regulation of response to endoplasmic reticulum stress] GO:2001199 [negative regulation of dendritic cell differentiation] Show all	310 aa 34 kDa	Yes	1
FCGR2B-203 ENSP00000356938 ENST00000367961	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001540 [amyloid-beta binding] GO:0001811 [negative regulation of type I hypersensitivity] GO:0001814 [negative regulation of antibody-dependent cellular cytotoxicity] GO:0002266 [follicular dendritic cell activation] GO:0002313 [mature B cell differentiation involved in immune response] GO:0002316 [follicular B cell differentiation] GO:0002436 [immune complex clearance by monocytes and macrophages] GO:0002605 [negative regulation of dendritic cell antigen processing and presentation] GO:0002622 [regulation of B cell antigen processing and presentation] GO:0002638 [negative regulation of immunoglobulin production] GO:0002819 [regulation of adaptive immune response] GO:0002865 [negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922 [positive regulation of humoral immune response] GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006911 [phagocytosis, engulfment] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0009617 [response to bacterium] GO:0009897 [external side of plasma membrane] GO:0010469 [regulation of receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016064 [immunoglobulin mediated immune response] GO:0019772 [low-affinity IgG receptor activity] GO:0019864 [IgG binding] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549 [cerebellum development] GO:0030889 [negative regulation of B cell proliferation] GO:0032693 [negative regulation of interleukin-10 production] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031 [negative regulation of macrophage activation] GO:0043197 [dendritic spine] GO:0043318 [negative regulation of cytotoxic T cell degranulation] GO:0044297 [cell body] GO:0044877 [macromolecular complex binding] GO:0045088 [regulation of innate immune response] GO:0046330 [positive regulation of JNK cascade] GO:0050710 [negative regulation of cytokine secretion] GO:0050765 [negative regulation of phagocytosis] GO:0050766 [positive regulation of phagocytosis] GO:0050776 [regulation of immune response] GO:0050777 [negative regulation of immune response] GO:0050869 [negative regulation of B cell activation] GO:0071219 [cellular response to molecule of bacterial origin] GO:0090264 [regulation of immune complex clearance by monocytes and macrophages] GO:1901216 [positive regulation of neuron death] GO:1902564 [negative regulation of neutrophil activation] GO:1902950 [regulation of dendritic spine maintenance] GO:1904646 [cellular response to amyloid-beta] GO:1905898 [positive regulation of response to endoplasmic reticulum stress] GO:2001199 [negative regulation of dendritic cell differentiation] Show all	303 aa 33.4 kDa	No	1

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