Cell type atlas - TFRC - The Human Protein Atlas

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TFRC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TFRC
Gene descriptionⁱ Full gene name according to HGNC.	Transferrin receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes Enzymes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	30 NX
Colon	76 NX
Liver	30 NX
Kidney	9 NX

Basal glandular cells	34 NX
Prostate	34 NX

Basal keratinocytes	54 NX
Skin	54 NX

Bipolar cells	48 NX
Eye	48 NX

Cardiomyocytes	82 NX
Heart muscle	82 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	26 NX
Lung	26 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	139 NX
Eye	139 NX

Cytotrophoblasts	104 NX
Placenta	104 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	18 NX
Eye	119 NX
Skin	28 NX
Pancreas	22 NX
Placenta	18 NX
Heart muscle	16 NX
Prostate	15 NX
Lung	12 NX
Liver	7 NX
Testis	3 NX

Enterocytes	72 NX
Rectum	155 NX
Colon	108 NX
Small intestine	47 NX

Erythroid cells	561 NX
Liver	561 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	34 NX
Placenta	92 NX
Lung	36 NX
Prostate	34 NX
Heart muscle	25 NX
Skin	21 NX

Glandular cells	16 NX
Prostate	16 NX

Granulocytes	22 NX
Lung	35 NX
Colon	9 NX

Hepatocytes	94 NX
Liver	94 NX

Hofbauer cells	70 NX
Placenta	70 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	54 NX
Colon	68 NX
Rectum	40 NX

Ito cells	7 NX
Liver	7 NX

Kupffer cells	33 NX
Liver	33 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	11 NX
Testis	11 NX

Macrophages	90 NX
Lung	244 NX
Pancreas	197 NX
Prostate	108 NX
Skin	63 NX
Testis	55 NX
Kidney	31 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	72 NX
Pancreas	72 NX

Mucus-secreting cells	50 NX
Colon	64 NX
Small intestine	59 NX
Rectum	43 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	39 NX
Pancreas	39 NX

Paneth cells	53 NX
Rectum	60 NX
Small intestine	53 NX
Colon	26 NX

Peritubular cells	8 NX
Testis	8 NX

Proximal tubular cells	9 NX
Kidney	9 NX

Rod photoreceptor cells	42 NX
Eye	42 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	35 NX
Skin	36 NX
Prostate	35 NX
Pancreas	35 NX
Heart muscle	27 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	19 NX
Testis	19 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	420 NX
Placenta	420 NX

T-cells	22 NX
Skin	66 NX
Colon	58 NX
Lung	39 NX
Prostate	22 NX
Liver	16 NX
Kidney	10 NX

Undifferentiated cells	70 NX
Small intestine	89 NX
Colon	84 NX
Rectum	58 NX

Urothelial cells	23 NX
Prostate	23 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.