Cell type atlas - RDH11 - The Human Protein Atlas

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RDH11

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RDH11
Gene descriptionⁱ Full gene name according to HGNC.	Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Muller glia cells, Glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Muller glia cells, Glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	58 NX
Lung	58 NX

B-cells	46 NX
Liver	66 NX
Kidney	49 NX
Colon	33 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	50 NX
Eye	50 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	74 NX
Liver	74 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	76 NX
Pancreas	76 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	38 NX
Pancreas	57 NX
Liver	49 NX
Lung	47 NX
Eye	44 NX
Prostate	38 NX
Heart muscle	37 NX
Testis	35 NX
Placenta	30 NX
Skin	17 NX

Enterocytes	23 NX
Colon	38 NX
Rectum	18 NX
Small intestine	16 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	74 NX
Pancreas	74 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	32 NX
Heart muscle	49 NX
Prostate	47 NX
Placenta	33 NX
Lung	25 NX
Skin	22 NX

Glandular cells	335 NX
Prostate	335 NX

Granulocytes	29 NX
Colon	37 NX
Lung	21 NX

Hepatocytes	125 NX
Liver	125 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	75 NX
Eye	75 NX

Intestinal endocrine cells	42 NX
Rectum	49 NX
Colon	34 NX

Ito cells	54 NX
Liver	54 NX

Kupffer cells	40 NX
Liver	40 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	40 NX
Testis	40 NX

Macrophages	34 NX
Pancreas	52 NX
Testis	40 NX
Lung	35 NX
Prostate	34 NX
Kidney	31 NX
Skin	16 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	39 NX
Pancreas	39 NX

Mucus-secreting cells	22 NX
Colon	35 NX
Small intestine	22 NX
Rectum	16 NX

Muller glia cells	352 NX
Eye	352 NX

Pancreatic endocrine cells	48 NX
Pancreas	48 NX

Paneth cells	35 NX
Small intestine	49 NX
Colon	35 NX
Rectum	16 NX

Peritubular cells	53 NX
Testis	53 NX

Proximal tubular cells	57 NX
Kidney	57 NX

Rod photoreceptor cells	95 NX
Eye	95 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	31 NX
Pancreas	81 NX
Prostate	43 NX
Heart muscle	29 NX
Skin	23 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	14 NX
Testis	14 NX

Suprabasal keratinocytes	17 NX
Skin	17 NX

Syncytiotrophoblasts	53 NX
Placenta	53 NX

T-cells	31 NX
Kidney	42 NX
Prostate	39 NX
Colon	33 NX
Skin	31 NX
Liver	29 NX
Lung	23 NX

Undifferentiated cells	16 NX
Colon	25 NX
Rectum	16 NX
Small intestine	16 NX

Urothelial cells	29 NX
Prostate	29 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.