Cell type atlas - PABPC1 - The Human Protein Atlas

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PABPC1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PABPC1
Gene descriptionⁱ Full gene name according to HGNC.	Poly(A) binding protein cytoplasmic 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	345 NX
Lung	345 NX

Alveolar cells type 2	848 NX
Lung	848 NX

B-cells	974 NX
Liver	1104 NX
Kidney	900 NX
Colon	790 NX

Basal glandular cells	893 NX
Prostate	893 NX

Basal keratinocytes	700 NX
Skin	700 NX

Bipolar cells	57 NX
Eye	57 NX

Cardiomyocytes	120 NX
Heart muscle	120 NX

Cholangiocytes	413 NX
Liver	413 NX

Ciliated cells	665 NX
Lung	665 NX

Club cells	1209 NX
Lung	1209 NX

Collecting duct cells	105 NX
Kidney	105 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	409 NX
Placenta	409 NX

Distal tubular cells	224 NX
Kidney	224 NX

Ductal cells	411 NX
Pancreas	411 NX

Early spermatids	1290 NX
Testis	1290 NX

Endothelial cells	467 NX
Liver	933 NX
Lung	843 NX
Prostate	597 NX
Placenta	551 NX
Skin	502 NX
Testis	467 NX
Eye	325 NX
Pancreas	258 NX
Heart muscle	217 NX

Enterocytes	397 NX
Rectum	439 NX
Small intestine	388 NX
Colon	360 NX

Erythroid cells	444 NX
Liver	444 NX

Exocrine glandular cells	663 NX
Pancreas	663 NX

Extravillous trophoblasts	702 NX
Placenta	702 NX

Fibroblasts	353 NX
Lung	1567 NX
Prostate	432 NX
Skin	410 NX
Placenta	297 NX
Heart muscle	209 NX

Glandular cells	475 NX
Prostate	475 NX

Granulocytes	996 NX
Lung	1532 NX
Colon	459 NX

Hepatocytes	223 NX
Liver	223 NX

Hofbauer cells	550 NX
Placenta	550 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	458 NX
Rectum	461 NX
Colon	455 NX

Ito cells	555 NX
Liver	555 NX

Kupffer cells	1326 NX
Liver	1326 NX

Late spermatids	159 NX
Testis	159 NX

Leydig cells	462 NX
Testis	462 NX

Macrophages	1051 NX
Lung	1991 NX
Prostate	1117 NX
Testis	1005 NX
Skin	863 NX
Kidney	834 NX
Pancreas	466 NX

Melanocytes	351 NX
Skin	351 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	954 NX
Pancreas	954 NX

Mucus-secreting cells	756 NX
Rectum	1040 NX
Colon	723 NX
Small intestine	493 NX

Muller glia cells	119 NX
Eye	119 NX

Pancreatic endocrine cells	570 NX
Pancreas	570 NX

Paneth cells	463 NX
Rectum	1009 NX
Small intestine	463 NX
Colon	423 NX

Peritubular cells	399 NX
Testis	399 NX

Proximal tubular cells	264 NX
Kidney	264 NX

Rod photoreceptor cells	88 NX
Eye	88 NX

Sertoli cells	492 NX
Testis	492 NX

Smooth muscle cells	507 NX
Skin	632 NX
Prostate	616 NX
Pancreas	431 NX
Heart muscle	299 NX

Spermatocytes	1313 NX
Testis	1313 NX

Spermatogonia	244 NX
Testis	244 NX

Suprabasal keratinocytes	669 NX
Skin	669 NX

Syncytiotrophoblasts	651 NX
Placenta	651 NX

T-cells	840 NX
Lung	1597 NX
Liver	878 NX
Skin	844 NX
Colon	840 NX
Kidney	678 NX
Prostate	580 NX

Undifferentiated cells	924 NX
Rectum	1010 NX
Small intestine	967 NX
Colon	652 NX

Urothelial cells	1044 NX
Prostate	1044 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.