Cell type atlas - ATP1B3 - The Human Protein Atlas

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ATP1B3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP1B3
Gene descriptionⁱ Full gene name according to HGNC.	ATPase Na+/K+ transporting subunit beta 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	47 NX
Lung	46 NX

B-cells	110 NX
Colon	206 NX
Liver	103 NX
Kidney	40 NX

Basal glandular cells	334 NX
Prostate	334 NX

Basal keratinocytes	438 NX
Skin	438 NX

Bipolar cells	35 NX
Eye	35 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	209 NX
Kidney	209 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	256 NX
Placenta	256 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	72 NX
Pancreas	72 NX

Early spermatids	392 NX
Testis	392 NX

Endothelial cells	178 NX
Prostate	514 NX
Pancreas	337 NX
Placenta	264 NX
Skin	205 NX
Eye	179 NX
Testis	122 NX
Lung	99 NX
Liver	76 NX
Heart muscle	67 NX

Enterocytes	384 NX
Rectum	1271 NX
Colon	384 NX
Small intestine	358 NX

Erythroid cells	140 NX
Liver	140 NX

Exocrine glandular cells	53 NX
Pancreas	53 NX

Extravillous trophoblasts	200 NX
Placenta	200 NX

Fibroblasts	110 NX
Prostate	826 NX
Placenta	123 NX
Skin	107 NX
Lung	81 NX
Heart muscle	41 NX

Glandular cells	121 NX
Prostate	121 NX

Granulocytes	129 NX
Colon	165 NX
Lung	93 NX

Hepatocytes	6 NX
Liver	6 NX

Hofbauer cells	276 NX
Placenta	276 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	54 NX
Colon	68 NX
Rectum	40 NX

Ito cells	80 NX
Liver	80 NX

Kupffer cells	137 NX
Liver	137 NX

Late spermatids	712 NX
Testis	712 NX

Leydig cells	79 NX
Testis	79 NX

Macrophages	209 NX
Prostate	831 NX
Skin	404 NX
Pancreas	260 NX
Testis	214 NX
Kidney	204 NX
Lung	162 NX

Melanocytes	211 NX
Skin	211 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	518 NX
Pancreas	518 NX

Mucus-secreting cells	67 NX
Small intestine	76 NX
Rectum	64 NX
Colon	42 NX

Muller glia cells	43 NX
Eye	43 NX

Pancreatic endocrine cells	55 NX
Pancreas	55 NX

Paneth cells	123 NX
Colon	671 NX
Rectum	123 NX
Small intestine	56 NX

Peritubular cells	64 NX
Testis	64 NX

Proximal tubular cells	30 NX
Kidney	30 NX

Rod photoreceptor cells	25 NX
Eye	25 NX

Sertoli cells	123 NX
Testis	123 NX

Smooth muscle cells	189 NX
Prostate	843 NX
Skin	595 NX
Pancreas	189 NX
Heart muscle	55 NX

Spermatocytes	42 NX
Testis	42 NX

Spermatogonia	191 NX
Testis	191 NX

Suprabasal keratinocytes	362 NX
Skin	362 NX

Syncytiotrophoblasts	327 NX
Placenta	327 NX

T-cells	66 NX
Colon	313 NX
Skin	301 NX
Prostate	248 NX
Kidney	80 NX
Liver	55 NX
Lung	45 NX

Undifferentiated cells	110 NX
Small intestine	129 NX
Colon	120 NX
Rectum	91 NX

Urothelial cells	362 NX
Prostate	362 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.