Cell type atlas - IP6K2 - The Human Protein Atlas

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IP6K2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IP6K2
Gene descriptionⁱ Full gene name according to HGNC.	Inositol hexakisphosphate kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	39 NX
Lung	39 NX

B-cells	24 NX
Kidney	49 NX
Colon	34 NX
Liver	13 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	74 NX
Skin	74 NX

Bipolar cells	64 NX
Eye	64 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	70 NX
Lung	70 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	94 NX
Kidney	94 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	101 NX
Placenta	101 NX

Distal tubular cells	65 NX
Kidney	65 NX

Ductal cells	52 NX
Pancreas	52 NX

Early spermatids	31 NX
Testis	31 NX

Endothelial cells	42 NX
Heart muscle	61 NX
Lung	55 NX
Placenta	48 NX
Pancreas	47 NX
Prostate	42 NX
Testis	39 NX
Eye	37 NX
Liver	36 NX
Skin	33 NX

Enterocytes	86 NX
Rectum	150 NX
Colon	97 NX
Small intestine	64 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	64 NX
Placenta	64 NX

Fibroblasts	64 NX
Heart muscle	129 NX
Placenta	74 NX
Prostate	70 NX
Lung	59 NX
Skin	43 NX

Glandular cells	60 NX
Prostate	60 NX

Granulocytes	53 NX
Colon	55 NX
Lung	51 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	106 NX
Colon	116 NX
Rectum	96 NX

Ito cells	35 NX
Liver	35 NX

Kupffer cells	15 NX
Liver	15 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	75 NX
Testis	75 NX

Macrophages	31 NX
Lung	38 NX
Prostate	35 NX
Skin	31 NX
Kidney	20 NX
Testis	16 NX
Pancreas	12 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	34 NX
Pancreas	34 NX

Mucus-secreting cells	96 NX
Small intestine	105 NX
Colon	100 NX
Rectum	92 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	50 NX
Pancreas	50 NX

Paneth cells	90 NX
Colon	118 NX
Rectum	90 NX
Small intestine	77 NX

Peritubular cells	64 NX
Testis	64 NX

Proximal tubular cells	56 NX
Kidney	56 NX

Rod photoreceptor cells	50 NX
Eye	50 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	36 NX
Heart muscle	64 NX
Prostate	39 NX
Pancreas	36 NX
Skin	30 NX

Spermatocytes	57 NX
Testis	57 NX

Spermatogonia	54 NX
Testis	54 NX

Suprabasal keratinocytes	73 NX
Skin	73 NX

Syncytiotrophoblasts	104 NX
Placenta	104 NX

T-cells	47 NX
Prostate	57 NX
Lung	55 NX
Kidney	47 NX
Colon	47 NX
Liver	45 NX
Skin	33 NX

Undifferentiated cells	79 NX
Rectum	82 NX
Colon	67 NX
Small intestine	65 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.