Cell type atlas - ACSL4 - The Human Protein Atlas

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ACSL4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACSL4
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA synthetase long chain family member 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (granulocytes, Alveolar cells type 2)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (granulocytes, Alveolar cells type 2)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	72 NX
Lung	72 NX

Alveolar cells type 2	211 NX
Lung	211 NX

B-cells	21 NX
Liver	33 NX
Kidney	13 NX
Colon	11 NX

Basal glandular cells	16 NX
Prostate	16 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	35 NX
Eye	35 NX

Cardiomyocytes	32 NX
Heart muscle	32 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	65 NX
Lung	65 NX

Collecting duct cells	70 NX
Kidney	70 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	6 NX
Placenta	6 NX

Distal tubular cells	43 NX
Kidney	43 NX

Ductal cells	24 NX
Pancreas	24 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	29 NX
Lung	58 NX
Prostate	36 NX
Heart muscle	33 NX
Liver	32 NX
Pancreas	32 NX
Eye	29 NX
Testis	18 NX
Skin	13 NX
Placenta	6 NX

Enterocytes	1 NX
Rectum	1 NX
Colon	1 NX
Small intestine	1 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	22 NX
Pancreas	22 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	18 NX
Lung	105 NX
Prostate	85 NX
Heart muscle	24 NX
Skin	16 NX
Placenta	7 NX

Glandular cells	11 NX
Prostate	11 NX

Granulocytes	598 NX
Lung	930 NX
Colon	266 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	8 NX
Colon	10 NX
Rectum	5 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	68 NX
Liver	68 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	5 NX
Testis	5 NX

Macrophages	45 NX
Lung	137 NX
Kidney	45 NX
Prostate	45 NX
Skin	43 NX
Pancreas	42 NX
Testis	35 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	65 NX
Pancreas	65 NX

Mucus-secreting cells	3 NX
Small intestine	7 NX
Rectum	3 NX
Colon	3 NX

Muller glia cells	12 NX
Eye	12 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	1 NX
Small intestine	7 NX
Rectum	1 NX
Colon	0 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	15 NX
Eye	15 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	22 NX
Pancreas	35 NX
Prostate	23 NX
Heart muscle	22 NX
Skin	9 NX

Spermatocytes	4 NX
Testis	4 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	7 NX
Skin	7 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	14 NX
Lung	79 NX
Prostate	35 NX
Liver	17 NX
Colon	10 NX
Skin	10 NX
Kidney	8 NX

Undifferentiated cells	2 NX
Small intestine	3 NX
Colon	2 NX
Rectum	1 NX

Urothelial cells	12 NX
Prostate	12 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.