Cell type atlas - ROCK1 - The Human Protein Atlas

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ROCK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ROCK1
Gene descriptionⁱ Full gene name according to HGNC.	Rho associated coiled-coil containing protein kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	78 NX
Lung	78 NX

B-cells	62 NX
Colon	148 NX
Liver	61 NX
Kidney	36 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	41 NX
Skin	41 NX

Bipolar cells	96 NX
Eye	96 NX

Cardiomyocytes	124 NX
Heart muscle	124 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	86 NX
Lung	86 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	124 NX
Eye	124 NX

Cytotrophoblasts	48 NX
Placenta	48 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	336 NX
Testis	336 NX

Endothelial cells	73 NX
Heart muscle	150 NX
Eye	130 NX
Testis	111 NX
Prostate	97 NX
Lung	73 NX
Liver	65 NX
Pancreas	61 NX
Placenta	53 NX
Skin	51 NX

Enterocytes	31 NX
Colon	34 NX
Small intestine	31 NX
Rectum	30 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	33 NX
Pancreas	33 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	65 NX
Lung	108 NX
Heart muscle	100 NX
Prostate	70 NX
Placenta	64 NX
Skin	61 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	70 NX
Lung	93 NX
Colon	46 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	55 NX
Placenta	55 NX

Horizontal cells	57 NX
Eye	57 NX

Intestinal endocrine cells	95 NX
Colon	129 NX
Rectum	61 NX

Ito cells	46 NX
Liver	46 NX

Kupffer cells	128 NX
Liver	128 NX

Late spermatids	391 NX
Testis	391 NX

Leydig cells	90 NX
Testis	90 NX

Macrophages	133 NX
Testis	243 NX
Lung	185 NX
Prostate	150 NX
Skin	106 NX
Pancreas	80 NX
Kidney	62 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	86 NX
Pancreas	86 NX

Mucus-secreting cells	38 NX
Colon	47 NX
Rectum	39 NX
Small intestine	35 NX

Muller glia cells	48 NX
Eye	48 NX

Pancreatic endocrine cells	52 NX
Pancreas	52 NX

Paneth cells	60 NX
Small intestine	67 NX
Colon	60 NX
Rectum	43 NX

Peritubular cells	130 NX
Testis	130 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	135 NX
Eye	135 NX

Sertoli cells	168 NX
Testis	168 NX

Smooth muscle cells	158 NX
Heart muscle	369 NX
Prostate	171 NX
Skin	137 NX
Pancreas	63 NX

Spermatocytes	69 NX
Testis	69 NX

Spermatogonia	77 NX
Testis	77 NX

Suprabasal keratinocytes	32 NX
Skin	32 NX

Syncytiotrophoblasts	36 NX
Placenta	36 NX

T-cells	96 NX
Colon	161 NX
Liver	103 NX
Lung	96 NX
Skin	91 NX
Kidney	83 NX
Prostate	74 NX

Undifferentiated cells	35 NX
Small intestine	36 NX
Colon	35 NX
Rectum	34 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.