Cell type atlas - IDH3G - The Human Protein Atlas

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IDH3G

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IDH3G
Gene descriptionⁱ Full gene name according to HGNC.	Isocitrate dehydrogenase 3 (NAD(+)) gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Citric acid cycle related proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	57 NX
Kidney	71 NX
Colon	42 NX
Liver	37 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	72 NX
Skin	72 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	48 NX
Heart muscle	48 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	49 NX
Kidney	49 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	81 NX
Placenta	81 NX

Distal tubular cells	176 NX
Kidney	176 NX

Ductal cells	82 NX
Pancreas	82 NX

Early spermatids	114 NX
Testis	114 NX

Endothelial cells	44 NX
Pancreas	65 NX
Eye	62 NX
Placenta	54 NX
Skin	52 NX
Testis	46 NX
Liver	38 NX
Lung	29 NX
Prostate	28 NX
Heart muscle	20 NX

Enterocytes	164 NX
Small intestine	177 NX
Colon	168 NX
Rectum	71 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	79 NX
Pancreas	79 NX

Extravillous trophoblasts	83 NX
Placenta	83 NX

Fibroblasts	57 NX
Skin	60 NX
Placenta	58 NX
Prostate	31 NX
Heart muscle	28 NX
Lung	16 NX

Glandular cells	37 NX
Prostate	37 NX

Granulocytes	91 NX
Colon	92 NX
Lung	91 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	117 NX
Placenta	117 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	60 NX
Colon	61 NX
Rectum	59 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	89 NX
Liver	89 NX

Late spermatids	227 NX
Testis	227 NX

Leydig cells	50 NX
Testis	50 NX

Macrophages	66 NX
Kidney	115 NX
Pancreas	110 NX
Skin	67 NX
Testis	67 NX
Prostate	55 NX
Lung	47 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	101 NX
Pancreas	101 NX

Mucus-secreting cells	82 NX
Colon	125 NX
Small intestine	88 NX
Rectum	69 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	65 NX
Pancreas	65 NX

Paneth cells	123 NX
Colon	147 NX
Small intestine	123 NX
Rectum	92 NX

Peritubular cells	55 NX
Testis	55 NX

Proximal tubular cells	193 NX
Kidney	193 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	69 NX
Pancreas	89 NX
Prostate	71 NX
Skin	68 NX
Heart muscle	49 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	17 NX
Testis	17 NX

Suprabasal keratinocytes	68 NX
Skin	68 NX

Syncytiotrophoblasts	93 NX
Placenta	93 NX

T-cells	55 NX
Kidney	77 NX
Colon	65 NX
Skin	55 NX
Liver	55 NX
Prostate	48 NX
Lung	33 NX

Undifferentiated cells	93 NX
Colon	115 NX
Small intestine	111 NX
Rectum	69 NX

Urothelial cells	44 NX
Prostate	44 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.