Cell type atlas - DNTTIP2 - The Human Protein Atlas

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DNTTIP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNTTIP2
Gene descriptionⁱ Full gene name according to HGNC.	Deoxynucleotidyltransferase terminal interacting protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	74 NX
Lung	74 NX

B-cells	43 NX
Colon	73 NX
Kidney	45 NX
Liver	41 NX

Basal glandular cells	98 NX
Prostate	98 NX

Basal keratinocytes	48 NX
Skin	48 NX

Bipolar cells	32 NX
Eye	32 NX

Cardiomyocytes	69 NX
Heart muscle	69 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	118 NX
Lung	118 NX

Club cells	117 NX
Lung	117 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	55 NX
Eye	55 NX

Cytotrophoblasts	44 NX
Placenta	44 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	60 NX
Pancreas	60 NX

Early spermatids	29 NX
Testis	29 NX

Endothelial cells	61 NX
Prostate	137 NX
Lung	120 NX
Heart muscle	97 NX
Pancreas	97 NX
Skin	48 NX
Eye	46 NX
Placenta	37 NX
Testis	34 NX
Liver	22 NX

Enterocytes	13 NX
Small intestine	14 NX
Colon	12 NX
Rectum	11 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	53 NX
Pancreas	53 NX

Extravillous trophoblasts	37 NX
Placenta	37 NX

Fibroblasts	32 NX
Lung	117 NX
Prostate	96 NX
Heart muscle	71 NX
Placenta	30 NX
Skin	25 NX

Glandular cells	61 NX
Prostate	61 NX

Granulocytes	113 NX
Lung	179 NX
Colon	46 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	8 NX
Rectum	9 NX
Colon	7 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	24 NX
Liver	24 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	24 NX
Testis	24 NX

Macrophages	60 NX
Lung	128 NX
Pancreas	63 NX
Skin	57 NX
Prostate	56 NX
Testis	33 NX
Kidney	24 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	64 NX
Pancreas	64 NX

Mucus-secreting cells	12 NX
Colon	16 NX
Rectum	12 NX
Small intestine	6 NX

Muller glia cells	31 NX
Eye	31 NX

Pancreatic endocrine cells	69 NX
Pancreas	69 NX

Paneth cells	15 NX
Small intestine	28 NX
Rectum	15 NX
Colon	12 NX

Peritubular cells	24 NX
Testis	24 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	106 NX
Prostate	112 NX
Heart muscle	106 NX
Skin	85 NX
Pancreas	50 NX

Spermatocytes	54 NX
Testis	54 NX

Spermatogonia	71 NX
Testis	71 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	47 NX
Placenta	47 NX

T-cells	47 NX
Lung	145 NX
Skin	89 NX
Colon	83 NX
Prostate	74 NX
Kidney	47 NX
Liver	42 NX

Undifferentiated cells	20 NX
Colon	31 NX
Small intestine	22 NX
Rectum	12 NX

Urothelial cells	80 NX
Prostate	80 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.