Cell type atlas - IPO5 - The Human Protein Atlas

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IPO5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IPO5
Gene descriptionⁱ Full gene name according to HGNC.	Importin 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	24 NX
Lung	24 NX

B-cells	16 NX
Liver	25 NX
Colon	22 NX
Kidney	9 NX

Basal glandular cells	34 NX
Prostate	34 NX

Basal keratinocytes	37 NX
Skin	37 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	68 NX
Heart muscle	68 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	29 NX
Placenta	29 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	1043 NX
Testis	1043 NX

Endothelial cells	35 NX
Prostate	58 NX
Pancreas	50 NX
Lung	44 NX
Liver	43 NX
Heart muscle	38 NX
Testis	35 NX
Skin	27 NX
Placenta	24 NX
Eye	16 NX

Enterocytes	8 NX
Rectum	12 NX
Small intestine	8 NX
Colon	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	36 NX
Pancreas	36 NX

Extravillous trophoblasts	38 NX
Placenta	38 NX

Fibroblasts	34 NX
Prostate	61 NX
Skin	37 NX
Heart muscle	37 NX
Placenta	30 NX
Lung	29 NX

Glandular cells	36 NX
Prostate	36 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	21 NX
Placenta	21 NX

Horizontal cells	60 NX
Eye	60 NX

Intestinal endocrine cells	34 NX
Colon	37 NX
Rectum	31 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	24 NX
Liver	24 NX

Late spermatids	1438 NX
Testis	1438 NX

Leydig cells	49 NX
Testis	49 NX

Macrophages	19 NX
Prostate	31 NX
Testis	28 NX
Skin	24 NX
Lung	18 NX
Pancreas	14 NX
Kidney	14 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	14 NX
Pancreas	14 NX

Mucus-secreting cells	20 NX
Rectum	26 NX
Small intestine	22 NX
Colon	12 NX

Muller glia cells	41 NX
Eye	41 NX

Pancreatic endocrine cells	33 NX
Pancreas	33 NX

Paneth cells	4 NX
Rectum	26 NX
Small intestine	4 NX
Colon	3 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	36 NX
Kidney	36 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	49 NX
Pancreas	65 NX
Prostate	56 NX
Heart muscle	47 NX
Skin	41 NX

Spermatocytes	110 NX
Testis	110 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	32 NX
Skin	32 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	19 NX
Liver	25 NX
Colon	21 NX
Skin	20 NX
Kidney	19 NX
Prostate	18 NX
Lung	12 NX

Undifferentiated cells	37 NX
Rectum	42 NX
Small intestine	40 NX
Colon	28 NX

Urothelial cells	34 NX
Prostate	34 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.