Cell type atlas - GNAI3 - The Human Protein Atlas

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GNAI3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNAI3
Gene descriptionⁱ Full gene name according to HGNC.	G protein subunit alpha i3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	73 NX
Colon	93 NX
Kidney	76 NX
Liver	58 NX

Basal glandular cells	90 NX
Prostate	90 NX

Basal keratinocytes	134 NX
Skin	134 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	34 NX
Lung	34 NX

Collecting duct cells	56 NX
Kidney	56 NX

Cone photoreceptor cells	330 NX
Eye	330 NX

Cytotrophoblasts	74 NX
Placenta	74 NX

Distal tubular cells	55 NX
Kidney	55 NX

Ductal cells	95 NX
Pancreas	95 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	65 NX
Prostate	125 NX
Pancreas	82 NX
Eye	80 NX
Placenta	78 NX
Skin	76 NX
Testis	48 NX
Heart muscle	37 NX
Lung	32 NX
Liver	29 NX

Enterocytes	48 NX
Colon	65 NX
Rectum	54 NX
Small intestine	40 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	88 NX
Pancreas	88 NX

Extravillous trophoblasts	115 NX
Placenta	115 NX

Fibroblasts	72 NX
Skin	81 NX
Placenta	72 NX
Prostate	62 NX
Lung	55 NX
Heart muscle	41 NX

Glandular cells	62 NX
Prostate	62 NX

Granulocytes	45 NX
Colon	46 NX
Lung	44 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	96 NX
Placenta	96 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	81 NX
Colon	99 NX
Rectum	63 NX

Ito cells	48 NX
Liver	48 NX

Kupffer cells	103 NX
Liver	103 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	45 NX
Testis	45 NX

Macrophages	90 NX
Kidney	113 NX
Lung	93 NX
Skin	93 NX
Prostate	90 NX
Pancreas	87 NX
Testis	84 NX

Melanocytes	71 NX
Skin	71 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	78 NX
Pancreas	78 NX

Mucus-secreting cells	58 NX
Colon	87 NX
Rectum	57 NX
Small intestine	54 NX

Muller glia cells	44 NX
Eye	44 NX

Pancreatic endocrine cells	82 NX
Pancreas	82 NX

Paneth cells	53 NX
Colon	63 NX
Small intestine	53 NX
Rectum	44 NX

Peritubular cells	45 NX
Testis	45 NX

Proximal tubular cells	41 NX
Kidney	41 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	82 NX
Pancreas	114 NX
Skin	87 NX
Prostate	79 NX
Heart muscle	31 NX

Spermatocytes	64 NX
Testis	64 NX

Spermatogonia	49 NX
Testis	49 NX

Suprabasal keratinocytes	165 NX
Skin	165 NX

Syncytiotrophoblasts	89 NX
Placenta	89 NX

T-cells	83 NX
Skin	131 NX
Kidney	94 NX
Colon	90 NX
Prostate	83 NX
Liver	63 NX
Lung	58 NX

Undifferentiated cells	48 NX
Colon	81 NX
Small intestine	65 NX
Rectum	38 NX

Urothelial cells	148 NX
Prostate	148 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.