Cell type atlas - HIPK2 - The Human Protein Atlas

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HIPK2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIPK2
Gene descriptionⁱ Full gene name according to HGNC.	Homeodomain interacting protein kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	34 NX
Kidney	45 NX
Liver	38 NX
Colon	24 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	8 NX
Skin	8 NX

Bipolar cells	101 NX
Eye	101 NX

Cardiomyocytes	179 NX
Heart muscle	179 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	29 NX
Lung	29 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	61 NX
Kidney	61 NX

Cone photoreceptor cells	143 NX
Eye	143 NX

Cytotrophoblasts	6 NX
Placenta	6 NX

Distal tubular cells	30 NX
Kidney	30 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	44 NX
Liver	234 NX
Prostate	164 NX
Heart muscle	103 NX
Lung	50 NX
Placenta	44 NX
Pancreas	22 NX
Eye	20 NX
Testis	16 NX
Skin	15 NX

Enterocytes	23 NX
Rectum	42 NX
Colon	27 NX
Small intestine	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	59 NX
Pancreas	59 NX

Extravillous trophoblasts	2 NX
Placenta	2 NX

Fibroblasts	19 NX
Heart muscle	81 NX
Prostate	45 NX
Lung	21 NX
Placenta	20 NX
Skin	12 NX

Glandular cells	92 NX
Prostate	92 NX

Granulocytes	43 NX
Lung	58 NX
Colon	28 NX

Hepatocytes	128 NX
Liver	128 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	210 NX
Eye	210 NX

Intestinal endocrine cells	65 NX
Rectum	68 NX
Colon	61 NX

Ito cells	159 NX
Liver	159 NX

Kupffer cells	115 NX
Liver	115 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	12 NX
Testis	12 NX

Macrophages	29 NX
Prostate	71 NX
Lung	44 NX
Pancreas	42 NX
Kidney	34 NX
Testis	24 NX
Skin	11 NX

Melanocytes	42 NX
Skin	42 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	35 NX
Rectum	37 NX
Small intestine	24 NX
Colon	18 NX

Muller glia cells	61 NX
Eye	61 NX

Pancreatic endocrine cells	54 NX
Pancreas	54 NX

Paneth cells	18 NX
Rectum	38 NX
Small intestine	18 NX
Colon	12 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	63 NX
Kidney	63 NX

Rod photoreceptor cells	60 NX
Eye	60 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	64 NX
Prostate	143 NX
Heart muscle	70 NX
Skin	47 NX
Pancreas	9 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	8 NX
Skin	8 NX

Syncytiotrophoblasts	8 NX
Placenta	8 NX

T-cells	30 NX
Liver	61 NX
Lung	30 NX
Prostate	22 NX
Kidney	20 NX
Colon	17 NX
Skin	12 NX

Undifferentiated cells	23 NX
Rectum	36 NX
Small intestine	22 NX
Colon	17 NX

Urothelial cells	40 NX
Prostate	40 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.