Cell type atlas - EPN1 - The Human Protein Atlas

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EPN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPN1
Gene descriptionⁱ Full gene name according to HGNC.	Epsin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HEK93)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	33 NX
Liver	40 NX
Kidney	27 NX
Colon	25 NX

Basal glandular cells	24 NX
Prostate	24 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	40 NX
Placenta	40 NX

Distal tubular cells	101 NX
Kidney	101 NX

Ductal cells	45 NX
Pancreas	45 NX

Early spermatids	51 NX
Testis	51 NX

Endothelial cells	30 NX
Liver	85 NX
Placenta	58 NX
Testis	43 NX
Pancreas	36 NX
Skin	32 NX
Prostate	29 NX
Eye	28 NX
Lung	15 NX
Heart muscle	10 NX

Enterocytes	274 NX
Small intestine	321 NX
Rectum	187 NX
Colon	182 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	77 NX
Pancreas	77 NX

Extravillous trophoblasts	66 NX
Placenta	66 NX

Fibroblasts	31 NX
Placenta	38 NX
Lung	31 NX
Skin	30 NX
Prostate	19 NX
Heart muscle	7 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	96 NX
Liver	96 NX

Hofbauer cells	54 NX
Placenta	54 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	43 NX
Rectum	49 NX
Colon	37 NX

Ito cells	78 NX
Liver	78 NX

Kupffer cells	103 NX
Liver	103 NX

Late spermatids	122 NX
Testis	122 NX

Leydig cells	44 NX
Testis	44 NX

Macrophages	37 NX
Pancreas	49 NX
Kidney	47 NX
Prostate	45 NX
Testis	38 NX
Lung	24 NX
Skin	22 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	109 NX
Small intestine	138 NX
Rectum	105 NX
Colon	77 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	78 NX
Pancreas	78 NX

Paneth cells	137 NX
Colon	187 NX
Small intestine	137 NX
Rectum	129 NX

Peritubular cells	50 NX
Testis	50 NX

Proximal tubular cells	53 NX
Kidney	53 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	22 NX
Pancreas	62 NX
Prostate	23 NX
Skin	19 NX
Heart muscle	9 NX

Spermatocytes	45 NX
Testis	45 NX

Spermatogonia	57 NX
Testis	57 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	22 NX
Kidney	26 NX
Colon	24 NX
Liver	22 NX
Prostate	22 NX
Skin	19 NX
Lung	16 NX

Undifferentiated cells	113 NX
Small intestine	117 NX
Colon	110 NX
Rectum	104 NX

Urothelial cells	33 NX
Prostate	33 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.