Cell type atlas - EIF4B - The Human Protein Atlas

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EIF4B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF4B
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 4B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	137 NX
Lung	137 NX

Alveolar cells type 2	177 NX
Lung	177 NX

B-cells	172 NX
Colon	239 NX
Liver	171 NX
Kidney	169 NX

Basal glandular cells	216 NX
Prostate	216 NX

Basal keratinocytes	185 NX
Skin	185 NX

Bipolar cells	82 NX
Eye	82 NX

Cardiomyocytes	129 NX
Heart muscle	129 NX

Cholangiocytes	163 NX
Liver	163 NX

Ciliated cells	127 NX
Lung	127 NX

Club cells	185 NX
Lung	185 NX

Collecting duct cells	89 NX
Kidney	89 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	124 NX
Placenta	124 NX

Distal tubular cells	154 NX
Kidney	154 NX

Ductal cells	106 NX
Pancreas	106 NX

Early spermatids	198 NX
Testis	198 NX

Endothelial cells	120 NX
Liver	272 NX
Testis	232 NX
Skin	202 NX
Prostate	191 NX
Lung	120 NX
Placenta	116 NX
Eye	104 NX
Heart muscle	61 NX
Pancreas	39 NX

Enterocytes	132 NX
Small intestine	163 NX
Colon	105 NX
Rectum	91 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	150 NX
Pancreas	150 NX

Extravillous trophoblasts	204 NX
Placenta	204 NX

Fibroblasts	129 NX
Lung	251 NX
Skin	132 NX
Prostate	131 NX
Placenta	110 NX
Heart muscle	92 NX

Glandular cells	182 NX
Prostate	182 NX

Granulocytes	227 NX
Lung	270 NX
Colon	184 NX

Hepatocytes	169 NX
Liver	169 NX

Hofbauer cells	97 NX
Placenta	97 NX

Horizontal cells	60 NX
Eye	60 NX

Intestinal endocrine cells	179 NX
Colon	187 NX
Rectum	171 NX

Ito cells	164 NX
Liver	164 NX

Kupffer cells	258 NX
Liver	258 NX

Late spermatids	403 NX
Testis	403 NX

Leydig cells	187 NX
Testis	187 NX

Macrophages	156 NX
Prostate	197 NX
Testis	157 NX
Lung	157 NX
Kidney	155 NX
Skin	149 NX
Pancreas	33 NX

Melanocytes	133 NX
Skin	133 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	139 NX
Pancreas	139 NX

Mucus-secreting cells	168 NX
Rectum	215 NX
Colon	158 NX
Small intestine	122 NX

Muller glia cells	84 NX
Eye	84 NX

Pancreatic endocrine cells	157 NX
Pancreas	157 NX

Paneth cells	74 NX
Rectum	191 NX
Small intestine	74 NX
Colon	55 NX

Peritubular cells	184 NX
Testis	184 NX

Proximal tubular cells	206 NX
Kidney	206 NX

Rod photoreceptor cells	80 NX
Eye	80 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	161 NX
Prostate	220 NX
Skin	188 NX
Pancreas	80 NX
Heart muscle	48 NX

Spermatocytes	66 NX
Testis	66 NX

Spermatogonia	44 NX
Testis	44 NX

Suprabasal keratinocytes	206 NX
Skin	206 NX

Syncytiotrophoblasts	149 NX
Placenta	149 NX

T-cells	183 NX
Colon	221 NX
Liver	206 NX
Prostate	192 NX
Kidney	183 NX
Skin	168 NX
Lung	160 NX

Undifferentiated cells	189 NX
Small intestine	200 NX
Rectum	189 NX
Colon	180 NX

Urothelial cells	203 NX
Prostate	203 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.