Cell type atlas - WAPL - The Human Protein Atlas

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WAPL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WAPL
Gene descriptionⁱ Full gene name according to HGNC.	WAPL cohesin release factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	52 NX
Lung	52 NX

B-cells	22 NX
Kidney	31 NX
Liver	22 NX
Colon	0 NX

Basal glandular cells	40 NX
Prostate	40 NX

Basal keratinocytes	0 NX
Skin	0 NX

Bipolar cells	47 NX
Eye	47 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	62 NX
Testis	62 NX

Endothelial cells	29 NX
Prostate	47 NX
Lung	44 NX
Pancreas	36 NX
Eye	33 NX
Testis	32 NX
Liver	29 NX
Placenta	27 NX
Heart muscle	0 NX
Skin	0 NX

Enterocytes	16 NX
Rectum	33 NX
Small intestine	21 NX
Colon	0 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	46 NX
Pancreas	46 NX

Extravillous trophoblasts	25 NX
Placenta	25 NX

Fibroblasts	22 NX
Prostate	44 NX
Lung	38 NX
Placenta	26 NX
Skin	0 NX
Heart muscle	0 NX

Glandular cells	50 NX
Prostate	50 NX

Granulocytes	23 NX
Lung	47 NX
Colon	0 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	18 NX
Rectum	35 NX
Colon	0 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	49 NX
Liver	49 NX

Late spermatids	27 NX
Testis	27 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	50 NX
Lung	64 NX
Testis	62 NX
Pancreas	52 NX
Kidney	48 NX
Prostate	38 NX
Skin	0 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	57 NX
Pancreas	57 NX

Mucus-secreting cells	32 NX
Rectum	33 NX
Small intestine	25 NX
Colon	0 NX

Muller glia cells	45 NX
Eye	45 NX

Pancreatic endocrine cells	47 NX
Pancreas	47 NX

Paneth cells	37 NX
Small intestine	39 NX
Rectum	37 NX
Colon	0 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	27 NX
Kidney	27 NX

Rod photoreceptor cells	127 NX
Eye	127 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	0 NX
Prostate	48 NX
Pancreas	30 NX
Skin	0 NX
Heart muscle	0 NX

Spermatocytes	125 NX
Testis	125 NX

Spermatogonia	83 NX
Testis	83 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	64 NX
Placenta	64 NX

T-cells	39 NX
Liver	48 NX
Lung	40 NX
Kidney	39 NX
Prostate	35 NX
Colon	0 NX
Skin	0 NX

Undifferentiated cells	32 NX
Rectum	36 NX
Small intestine	32 NX
Colon	0 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.