Cell type atlas - SEC61A1 - The Human Protein Atlas

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SEC61A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEC61A1
Gene descriptionⁱ Full gene name according to HGNC.	Sec61 translocon alpha 1 subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	23 NX
Liver	93 NX
Colon	24 NX
Kidney	22 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	17 NX
Eye	17 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	33 NX
Eye	33 NX

Cytotrophoblasts	56 NX
Placenta	56 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	77 NX
Pancreas	77 NX

Early spermatids	36 NX
Testis	36 NX

Endothelial cells	36 NX
Pancreas	79 NX
Placenta	58 NX
Prostate	52 NX
Eye	42 NX
Skin	36 NX
Testis	25 NX
Liver	25 NX
Heart muscle	23 NX
Lung	18 NX

Enterocytes	74 NX
Colon	137 NX
Rectum	60 NX
Small intestine	51 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	133 NX
Pancreas	133 NX

Extravillous trophoblasts	103 NX
Placenta	103 NX

Fibroblasts	63 NX
Placenta	87 NX
Prostate	63 NX
Lung	42 NX
Skin	41 NX
Heart muscle	16 NX

Glandular cells	60 NX
Prostate	60 NX

Granulocytes	25 NX
Colon	28 NX
Lung	23 NX

Hepatocytes	101 NX
Liver	101 NX

Hofbauer cells	68 NX
Placenta	68 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	71 NX
Colon	78 NX
Rectum	63 NX

Ito cells	53 NX
Liver	53 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	27 NX
Pancreas	59 NX
Prostate	34 NX
Skin	30 NX
Testis	26 NX
Lung	26 NX
Kidney	25 NX

Melanocytes	32 NX
Skin	32 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	85 NX
Colon	239 NX
Rectum	80 NX
Small intestine	79 NX

Muller glia cells	25 NX
Eye	25 NX

Pancreatic endocrine cells	95 NX
Pancreas	95 NX

Paneth cells	53 NX
Colon	60 NX
Rectum	53 NX
Small intestine	21 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	23 NX
Kidney	23 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	34 NX
Pancreas	167 NX
Prostate	34 NX
Skin	30 NX
Heart muscle	12 NX

Spermatocytes	9 NX
Testis	9 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	107 NX
Placenta	107 NX

T-cells	25 NX
Colon	42 NX
Liver	30 NX
Prostate	26 NX
Kidney	25 NX
Lung	22 NX
Skin	19 NX

Undifferentiated cells	63 NX
Colon	107 NX
Small intestine	57 NX
Rectum	54 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.