Cell type atlas - EIF2AK2 - The Human Protein Atlas

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EIF2AK2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2AK2
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2 alpha kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	16 NX
Kidney	54 NX
Colon	21 NX
Liver	5 NX

Basal glandular cells	37 NX
Prostate	37 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	25 NX
Heart muscle	25 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	54 NX
Lung	54 NX

Club cells	58 NX
Lung	58 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	56 NX
Heart muscle	108 NX
Lung	102 NX
Eye	79 NX
Testis	76 NX
Liver	56 NX
Pancreas	50 NX
Prostate	47 NX
Placenta	41 NX
Skin	38 NX

Enterocytes	26 NX
Rectum	36 NX
Small intestine	27 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	72 NX
Placenta	72 NX

Fibroblasts	35 NX
Lung	44 NX
Placenta	35 NX
Heart muscle	35 NX
Prostate	34 NX
Skin	34 NX

Glandular cells	31 NX
Prostate	31 NX

Granulocytes	39 NX
Lung	51 NX
Colon	28 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	15 NX
Rectum	19 NX
Colon	10 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	22 NX
Liver	22 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	25 NX
Testis	88 NX
Lung	82 NX
Kidney	26 NX
Pancreas	23 NX
Prostate	22 NX
Skin	21 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	22 NX
Small intestine	24 NX
Rectum	23 NX
Colon	16 NX

Muller glia cells	49 NX
Eye	49 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	25 NX
Rectum	26 NX
Small intestine	25 NX
Colon	9 NX

Peritubular cells	79 NX
Testis	79 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	34 NX
Heart muscle	45 NX
Prostate	34 NX
Skin	33 NX
Pancreas	33 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	3 NX
Testis	3 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	34 NX
Placenta	34 NX

T-cells	30 NX
Kidney	36 NX
Liver	34 NX
Lung	30 NX
Prostate	26 NX
Colon	26 NX
Skin	23 NX

Undifferentiated cells	26 NX
Small intestine	31 NX
Rectum	25 NX
Colon	20 NX

Urothelial cells	36 NX
Prostate	36 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.