Cell type atlas - NOP58 - The Human Protein Atlas

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NOP58

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NOP58
Gene descriptionⁱ Full gene name according to HGNC.	NOP58 ribonucleoprotein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	101 NX
Lung	101 NX

Alveolar cells type 2	104 NX
Lung	104 NX

B-cells	73 NX
Colon	93 NX
Liver	85 NX
Kidney	54 NX

Basal glandular cells	103 NX
Prostate	103 NX

Basal keratinocytes	76 NX
Skin	76 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	69 NX
Heart muscle	69 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	96 NX
Lung	96 NX

Club cells	150 NX
Lung	150 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	68 NX
Placenta	68 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	12 NX
Testis	11 NX

Endothelial cells	57 NX
Pancreas	100 NX
Lung	99 NX
Heart muscle	80 NX
Prostate	78 NX
Placenta	51 NX
Skin	44 NX
Testis	34 NX
Liver	27 NX
Eye	27 NX

Enterocytes	15 NX
Colon	19 NX
Small intestine	16 NX
Rectum	9 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	76 NX
Placenta	76 NX

Fibroblasts	50 NX
Lung	216 NX
Heart muscle	82 NX
Prostate	78 NX
Placenta	57 NX
Skin	38 NX

Glandular cells	71 NX
Prostate	71 NX

Granulocytes	132 NX
Lung	163 NX
Colon	101 NX

Hepatocytes	44 NX
Liver	44 NX

Hofbauer cells	43 NX
Placenta	43 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	34 NX
Colon	44 NX
Rectum	23 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	17 NX
Liver	17 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	40 NX
Testis	40 NX

Macrophages	46 NX
Lung	116 NX
Prostate	63 NX
Pancreas	52 NX
Skin	40 NX
Kidney	36 NX
Testis	34 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	73 NX
Pancreas	73 NX

Mucus-secreting cells	32 NX
Colon	98 NX
Small intestine	31 NX
Rectum	30 NX

Muller glia cells	18 NX
Eye	18 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	11 NX
Rectum	34 NX
Small intestine	11 NX
Colon	3 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	44 NX
Eye	44 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	82 NX
Heart muscle	92 NX
Prostate	82 NX
Pancreas	82 NX
Skin	59 NX

Spermatocytes	59 NX
Testis	59 NX

Spermatogonia	55 NX
Testis	55 NX

Suprabasal keratinocytes	65 NX
Skin	65 NX

Syncytiotrophoblasts	57 NX
Placenta	57 NX

T-cells	62 NX
Prostate	283 NX
Lung	173 NX
Colon	138 NX
Skin	85 NX
Kidney	62 NX
Liver	51 NX

Undifferentiated cells	56 NX
Colon	100 NX
Small intestine	62 NX
Rectum	35 NX

Urothelial cells	84 NX
Prostate	84 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.