Cell type atlas - FOXN3 - The Human Protein Atlas

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FOXN3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FOXN3
Gene descriptionⁱ Full gene name according to HGNC.	Forkhead box N3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	42 NX
Colon	78 NX
Liver	42 NX
Kidney	36 NX

Basal glandular cells	20 NX
Prostate	20 NX

Basal keratinocytes	79 NX
Skin	79 NX

Bipolar cells	120 NX
Eye	120 NX

Cardiomyocytes	94 NX
Heart muscle	94 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	47 NX
Lung	47 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	9 NX
Pancreas	9 NX

Early spermatids	52 NX
Testis	52 NX

Endothelial cells	50 NX
Heart muscle	127 NX
Eye	72 NX
Skin	54 NX
Testis	50 NX
Placenta	37 NX
Lung	35 NX
Liver	29 NX
Prostate	21 NX
Pancreas	18 NX

Enterocytes	42 NX
Small intestine	65 NX
Rectum	48 NX
Colon	22 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	18 NX
Pancreas	18 NX

Extravillous trophoblasts	17 NX
Placenta	17 NX

Fibroblasts	36 NX
Skin	70 NX
Heart muscle	41 NX
Prostate	36 NX
Lung	33 NX
Placenta	26 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	13 NX
Colon	18 NX
Lung	7 NX

Hepatocytes	74 NX
Liver	74 NX

Hofbauer cells	38 NX
Placenta	38 NX

Horizontal cells	75 NX
Eye	75 NX

Intestinal endocrine cells	57 NX
Colon	58 NX
Rectum	56 NX

Ito cells	52 NX
Liver	52 NX

Kupffer cells	76 NX
Liver	76 NX

Late spermatids	27 NX
Testis	26 NX

Leydig cells	89 NX
Testis	89 NX

Macrophages	70 NX
Testis	131 NX
Skin	129 NX
Prostate	87 NX
Kidney	48 NX
Lung	47 NX
Pancreas	23 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	26 NX
Pancreas	26 NX

Mucus-secreting cells	40 NX
Rectum	49 NX
Small intestine	38 NX
Colon	14 NX

Muller glia cells	32 NX
Eye	32 NX

Pancreatic endocrine cells	15 NX
Pancreas	15 NX

Paneth cells	25 NX
Rectum	43 NX
Small intestine	25 NX
Colon	20 NX

Peritubular cells	80 NX
Testis	80 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	53 NX
Heart muscle	69 NX
Skin	58 NX
Prostate	49 NX
Pancreas	14 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	10 NX
Testis	10 NX

Suprabasal keratinocytes	129 NX
Skin	129 NX

Syncytiotrophoblasts	25 NX
Placenta	25 NX

T-cells	76 NX
Skin	88 NX
Liver	82 NX
Kidney	73 NX
Colon	67 NX
Lung	45 NX
Prostate	35 NX

Undifferentiated cells	44 NX
Small intestine	59 NX
Rectum	51 NX
Colon	11 NX

Urothelial cells	22 NX
Prostate	22 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.