Cell type atlas - MSMO1 - The Human Protein Atlas

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MSMO1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MSMO1
Gene descriptionⁱ Full gene name according to HGNC.	Methylsterol monooxygenase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (GAMG, Karpas-707, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	144 NX
Lung	144 NX

B-cells	36 NX
Liver	45 NX
Colon	40 NX
Kidney	31 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	68 NX
Lung	68 NX

Club cells	60 NX
Lung	60 NX

Collecting duct cells	66 NX
Kidney	66 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	47 NX
Placenta	47 NX

Distal tubular cells	30 NX
Kidney	30 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	18 NX
Placenta	96 NX
Prostate	53 NX
Heart muscle	19 NX
Eye	18 NX
Lung	18 NX
Liver	18 NX
Testis	16 NX
Skin	15 NX
Pancreas	11 NX

Enterocytes	71 NX
Colon	136 NX
Rectum	58 NX
Small intestine	43 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	63 NX
Pancreas	63 NX

Extravillous trophoblasts	72 NX
Placenta	72 NX

Fibroblasts	28 NX
Placenta	69 NX
Prostate	28 NX
Heart muscle	18 NX
Skin	15 NX
Lung	15 NX

Glandular cells	85 NX
Prostate	85 NX

Granulocytes	48 NX
Colon	83 NX
Lung	14 NX

Hepatocytes	234 NX
Liver	234 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	58 NX
Colon	95 NX
Rectum	21 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	30 NX
Liver	30 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	15 NX
Prostate	31 NX
Lung	22 NX
Kidney	20 NX
Pancreas	16 NX
Testis	10 NX
Skin	10 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	36 NX
Pancreas	36 NX

Mucus-secreting cells	42 NX
Colon	120 NX
Small intestine	34 NX
Rectum	31 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	59 NX
Pancreas	59 NX

Paneth cells	25 NX
Colon	187 NX
Small intestine	25 NX
Rectum	15 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	36 NX
Kidney	36 NX

Rod photoreceptor cells	47 NX
Eye	47 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	20 NX
Pancreas	62 NX
Prostate	43 NX
Heart muscle	19 NX
Skin	14 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	14 NX
Testis	14 NX

Suprabasal keratinocytes	101 NX
Skin	101 NX

Syncytiotrophoblasts	103 NX
Placenta	103 NX

T-cells	22 NX
Skin	33 NX
Lung	32 NX
Kidney	27 NX
Liver	21 NX
Colon	21 NX
Prostate	9 NX

Undifferentiated cells	21 NX
Colon	55 NX
Small intestine	21 NX
Rectum	17 NX

Urothelial cells	123 NX
Prostate	123 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.