Cell type atlas - HEBP2 - The Human Protein Atlas

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HEBP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HEBP2
Gene descriptionⁱ Full gene name according to HGNC.	Heme binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	47 NX
Kidney	54 NX
Liver	52 NX
Colon	40 NX

Basal glandular cells	255 NX
Prostate	255 NX

Basal keratinocytes	104 NX
Skin	104 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	137 NX
Heart muscle	137 NX

Cholangiocytes	196 NX
Liver	196 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	115 NX
Kidney	115 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	233 NX
Placenta	233 NX

Distal tubular cells	250 NX
Kidney	250 NX

Ductal cells	288 NX
Pancreas	288 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	77 NX
Pancreas	183 NX
Prostate	165 NX
Skin	98 NX
Liver	83 NX
Eye	77 NX
Testis	75 NX
Heart muscle	56 NX
Placenta	48 NX
Lung	9 NX

Enterocytes	152 NX
Colon	260 NX
Rectum	174 NX
Small intestine	96 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	502 NX
Pancreas	502 NX

Extravillous trophoblasts	349 NX
Placenta	349 NX

Fibroblasts	73 NX
Prostate	92 NX
Placenta	76 NX
Skin	67 NX
Heart muscle	52 NX
Lung	9 NX

Glandular cells	467 NX
Prostate	467 NX

Granulocytes	45 NX
Colon	64 NX
Lung	26 NX

Hepatocytes	480 NX
Liver	480 NX

Hofbauer cells	81 NX
Placenta	81 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	98 NX
Colon	119 NX
Rectum	77 NX

Ito cells	62 NX
Liver	62 NX

Kupffer cells	76 NX
Liver	76 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	63 NX
Testis	63 NX

Macrophages	56 NX
Kidney	109 NX
Prostate	99 NX
Pancreas	94 NX
Testis	57 NX
Skin	50 NX
Lung	24 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	62 NX
Pancreas	62 NX

Mucus-secreting cells	126 NX
Colon	208 NX
Rectum	129 NX
Small intestine	112 NX

Muller glia cells	47 NX
Eye	47 NX

Pancreatic endocrine cells	488 NX
Pancreas	488 NX

Paneth cells	135 NX
Colon	357 NX
Rectum	135 NX
Small intestine	109 NX

Peritubular cells	63 NX
Testis	63 NX

Proximal tubular cells	239 NX
Kidney	239 NX

Rod photoreceptor cells	26 NX
Eye	26 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	66 NX
Pancreas	178 NX
Prostate	115 NX
Heart muscle	66 NX
Skin	46 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	179 NX
Skin	179 NX

Syncytiotrophoblasts	244 NX
Placenta	244 NX

T-cells	50 NX
Kidney	92 NX
Prostate	65 NX
Colon	62 NX
Skin	50 NX
Liver	26 NX
Lung	9 NX

Undifferentiated cells	107 NX
Colon	141 NX
Small intestine	107 NX
Rectum	105 NX

Urothelial cells	1163 NX
Prostate	1163 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.