Cell type atlas - NEDD4L - The Human Protein Atlas

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NEDD4L

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NEDD4L
Gene descriptionⁱ Full gene name according to HGNC.	Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-reg)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Hep G2, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	235 NX
Lung	235 NX

Alveolar cells type 2	123 NX
Lung	123 NX

B-cells	3 NX
Colon	6 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	143 NX
Prostate	143 NX

Basal keratinocytes	100 NX
Skin	100 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	51 NX
Heart muscle	51 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	92 NX
Lung	92 NX

Club cells	166 NX
Lung	166 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	163 NX
Eye	163 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	41 NX
Kidney	41 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	19 NX
Testis	19 NX

Endothelial cells	9 NX
Liver	38 NX
Prostate	22 NX
Lung	20 NX
Skin	11 NX
Heart muscle	9 NX
Eye	9 NX
Pancreas	7 NX
Placenta	6 NX
Testis	4 NX

Enterocytes	128 NX
Colon	170 NX
Rectum	103 NX
Small intestine	97 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	4 NX
Placenta	4 NX

Fibroblasts	11 NX
Lung	27 NX
Prostate	17 NX
Heart muscle	14 NX
Placenta	13 NX
Skin	5 NX

Glandular cells	173 NX
Prostate	173 NX

Granulocytes	4 NX
Lung	7 NX
Colon	0 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	6 NX
Placenta	6 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	44 NX
Rectum	63 NX
Colon	24 NX

Ito cells	10 NX
Liver	10 NX

Kupffer cells	5 NX
Liver	5 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	3 NX
Testis	3 NX

Macrophages	12 NX
Prostate	56 NX
Kidney	14 NX
Lung	12 NX
Pancreas	12 NX
Skin	6 NX
Testis	5 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	190 NX
Rectum	260 NX
Colon	203 NX
Small intestine	129 NX

Muller glia cells	31 NX
Eye	31 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	77 NX
Colon	248 NX
Rectum	77 NX
Small intestine	63 NX

Peritubular cells	17 NX
Testis	17 NX

Proximal tubular cells	60 NX
Kidney	60 NX

Rod photoreceptor cells	8 NX
Eye	7 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	5 NX
Prostate	14 NX
Heart muscle	5 NX
Skin	5 NX
Pancreas	2 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	3 NX
Testis	3 NX

Suprabasal keratinocytes	46 NX
Skin	46 NX

Syncytiotrophoblasts	67 NX
Placenta	67 NX

T-cells	5 NX
Prostate	39 NX
Lung	20 NX
Kidney	8 NX
Colon	6 NX
Skin	5 NX
Liver	0 NX

Undifferentiated cells	64 NX
Rectum	67 NX
Colon	64 NX
Small intestine	51 NX

Urothelial cells	150 NX
Prostate	150 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.