Cell type atlas - TPR - The Human Protein Atlas

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TPR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPR
Gene descriptionⁱ Full gene name according to HGNC.	Translocated promoter region, nuclear basket protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	203 NX
Lung	203 NX

Alveolar cells type 2	98 NX
Lung	98 NX

B-cells	79 NX
Kidney	103 NX
Colon	87 NX
Liver	64 NX

Basal glandular cells	89 NX
Prostate	89 NX

Basal keratinocytes	90 NX
Skin	90 NX

Bipolar cells	87 NX
Eye	87 NX

Cardiomyocytes	161 NX
Heart muscle	161 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	134 NX
Lung	134 NX

Club cells	121 NX
Lung	121 NX

Collecting duct cells	56 NX
Kidney	56 NX

Cone photoreceptor cells	75 NX
Eye	75 NX

Cytotrophoblasts	117 NX
Placenta	117 NX

Distal tubular cells	20 NX
Kidney	20 NX

Ductal cells	88 NX
Pancreas	88 NX

Early spermatids	107 NX
Testis	107 NX

Endothelial cells	101 NX
Heart muscle	179 NX
Eye	130 NX
Lung	128 NX
Testis	114 NX
Prostate	101 NX
Placenta	99 NX
Liver	94 NX
Pancreas	90 NX
Skin	75 NX

Enterocytes	41 NX
Small intestine	47 NX
Colon	34 NX
Rectum	34 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	65 NX
Pancreas	65 NX

Extravillous trophoblasts	89 NX
Placenta	89 NX

Fibroblasts	87 NX
Lung	277 NX
Heart muscle	187 NX
Placenta	98 NX
Prostate	84 NX
Skin	81 NX

Glandular cells	63 NX
Prostate	63 NX

Granulocytes	78 NX
Lung	100 NX
Colon	55 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	63 NX
Placenta	63 NX

Horizontal cells	94 NX
Eye	94 NX

Intestinal endocrine cells	65 NX
Rectum	66 NX
Colon	65 NX

Ito cells	57 NX
Liver	57 NX

Kupffer cells	60 NX
Liver	60 NX

Late spermatids	24 NX
Testis	24 NX

Leydig cells	116 NX
Testis	116 NX

Macrophages	75 NX
Lung	154 NX
Testis	90 NX
Pancreas	77 NX
Kidney	71 NX
Skin	69 NX
Prostate	51 NX

Melanocytes	52 NX
Skin	52 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	148 NX
Pancreas	148 NX

Mucus-secreting cells	49 NX
Colon	67 NX
Small intestine	48 NX
Rectum	43 NX

Muller glia cells	93 NX
Eye	93 NX

Pancreatic endocrine cells	75 NX
Pancreas	75 NX

Paneth cells	53 NX
Rectum	58 NX
Small intestine	53 NX
Colon	43 NX

Peritubular cells	110 NX
Testis	110 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	104 NX
Eye	104 NX

Sertoli cells	129 NX
Testis	129 NX

Smooth muscle cells	83 NX
Heart muscle	199 NX
Skin	86 NX
Prostate	83 NX
Pancreas	78 NX

Spermatocytes	640 NX
Testis	640 NX

Spermatogonia	240 NX
Testis	240 NX

Suprabasal keratinocytes	87 NX
Skin	87 NX

Syncytiotrophoblasts	126 NX
Placenta	126 NX

T-cells	97 NX
Lung	164 NX
Kidney	126 NX
Colon	113 NX
Prostate	100 NX
Skin	97 NX
Liver	81 NX

Undifferentiated cells	65 NX
Colon	77 NX
Small intestine	65 NX
Rectum	63 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.