Cell type atlas - CAPG - The Human Protein Atlas

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CAPG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CAPG
Gene descriptionⁱ Full gene name according to HGNC.	Capping actin protein, gelsolin like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, monocytes, granulocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, classical monocyte, plasmacytoid DC, basophil, eosinophil, memory B-cell, NK-cell, naive B-cell, intermediate monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CAPAN-2, HMC-1, SK-MEL-30, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, monocytes, granulocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	86 NX
Kidney	120 NX
Colon	117 NX
Liver	32 NX

Basal glandular cells	131 NX
Prostate	131 NX

Basal keratinocytes	108 NX
Skin	108 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	300 NX
Kidney	300 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	25 NX
Placenta	25 NX

Distal tubular cells	179 NX
Kidney	179 NX

Ductal cells	90 NX
Pancreas	90 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	6 NX
Eye	80 NX
Skin	41 NX
Placenta	17 NX
Prostate	15 NX
Testis	6 NX
Lung	6 NX
Liver	2 NX
Heart muscle	2 NX
Pancreas	0 NX

Enterocytes	101 NX
Colon	214 NX
Rectum	108 NX
Small intestine	55 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	81 NX
Pancreas	81 NX

Extravillous trophoblasts	260 NX
Placenta	260 NX

Fibroblasts	56 NX
Skin	103 NX
Placenta	47 NX
Prostate	20 NX
Lung	14 NX
Heart muscle	8 NX

Glandular cells	65 NX
Prostate	64 NX

Granulocytes	536 NX
Colon	569 NX
Lung	502 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	1103 NX
Placenta	1103 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	28 NX
Rectum	28 NX
Colon	27 NX

Ito cells	3 NX
Liver	3 NX

Kupffer cells	176 NX
Liver	175 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	43 NX
Testis	43 NX

Macrophages	306 NX
Pancreas	1879 NX
Prostate	466 NX
Testis	405 NX
Skin	305 NX
Kidney	305 NX
Lung	210 NX

Melanocytes	140 NX
Skin	140 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	603 NX
Pancreas	603 NX

Mucus-secreting cells	56 NX
Colon	60 NX
Rectum	57 NX
Small intestine	34 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	258 NX
Pancreas	258 NX

Paneth cells	119 NX
Colon	328 NX
Rectum	119 NX
Small intestine	102 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	89 NX
Kidney	89 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	24 NX
Skin	28 NX
Pancreas	24 NX
Prostate	9 NX
Heart muscle	2 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	40 NX
Testis	40 NX

Suprabasal keratinocytes	148 NX
Skin	148 NX

Syncytiotrophoblasts	30 NX
Placenta	30 NX

T-cells	60 NX
Skin	246 NX
Prostate	187 NX
Colon	152 NX
Lung	88 NX
Kidney	60 NX
Liver	14 NX

Undifferentiated cells	87 NX
Colon	102 NX
Rectum	87 NX
Small intestine	33 NX

Urothelial cells	209 NX
Prostate	209 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.