Cell type atlas - PSMA4 - The Human Protein Atlas

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PSMA4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMA4
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome subunit alpha 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	119 NX
Lung	119 NX

Alveolar cells type 2	94 NX
Lung	94 NX

B-cells	159 NX
Kidney	205 NX
Liver	184 NX
Colon	112 NX

Basal glandular cells	222 NX
Prostate	222 NX

Basal keratinocytes	206 NX
Skin	206 NX

Bipolar cells	52 NX
Eye	52 NX

Cardiomyocytes	152 NX
Heart muscle	152 NX

Cholangiocytes	115 NX
Liver	115 NX

Ciliated cells	165 NX
Lung	165 NX

Club cells	122 NX
Lung	122 NX

Collecting duct cells	115 NX
Kidney	115 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	397 NX
Placenta	397 NX

Distal tubular cells	264 NX
Kidney	264 NX

Ductal cells	267 NX
Pancreas	267 NX

Early spermatids	515 NX
Testis	515 NX

Endothelial cells	152 NX
Pancreas	358 NX
Placenta	271 NX
Prostate	215 NX
Skin	157 NX
Testis	142 NX
Heart muscle	127 NX
Lung	117 NX
Liver	92 NX
Eye	44 NX

Enterocytes	149 NX
Small intestine	170 NX
Colon	140 NX
Rectum	99 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	255 NX
Pancreas	255 NX

Extravillous trophoblasts	368 NX
Placenta	368 NX

Fibroblasts	172 NX
Placenta	269 NX
Lung	174 NX
Prostate	171 NX
Skin	166 NX
Heart muscle	114 NX

Glandular cells	213 NX
Prostate	213 NX

Granulocytes	170 NX
Colon	175 NX
Lung	165 NX

Hepatocytes	170 NX
Liver	170 NX

Hofbauer cells	287 NX
Placenta	287 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	140 NX
Colon	187 NX
Rectum	94 NX

Ito cells	109 NX
Liver	109 NX

Kupffer cells	138 NX
Liver	138 NX

Late spermatids	239 NX
Testis	239 NX

Leydig cells	140 NX
Testis	140 NX

Macrophages	215 NX
Kidney	356 NX
Pancreas	260 NX
Lung	253 NX
Prostate	191 NX
Skin	182 NX
Testis	159 NX

Melanocytes	127 NX
Skin	127 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	343 NX
Pancreas	343 NX

Mucus-secreting cells	139 NX
Colon	307 NX
Rectum	136 NX
Small intestine	127 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	231 NX
Pancreas	231 NX

Paneth cells	135 NX
Small intestine	189 NX
Rectum	135 NX
Colon	127 NX

Peritubular cells	139 NX
Testis	139 NX

Proximal tubular cells	289 NX
Kidney	289 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	149 NX
Testis	149 NX

Smooth muscle cells	178 NX
Pancreas	346 NX
Heart muscle	188 NX
Prostate	178 NX
Skin	153 NX

Spermatocytes	258 NX
Testis	258 NX

Spermatogonia	168 NX
Testis	168 NX

Suprabasal keratinocytes	186 NX
Skin	186 NX

Syncytiotrophoblasts	374 NX
Placenta	374 NX

T-cells	157 NX
Kidney	229 NX
Lung	163 NX
Prostate	157 NX
Liver	144 NX
Skin	138 NX
Colon	116 NX

Undifferentiated cells	171 NX
Colon	299 NX
Small intestine	231 NX
Rectum	143 NX

Urothelial cells	236 NX
Prostate	236 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.