Cell type atlas - TRIO - The Human Protein Atlas

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TRIO

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIO
Gene descriptionⁱ Full gene name according to HGNC.	Trio Rho guanine nucleotide exchange factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Leydig cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Leydig cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	9 NX
Kidney	9 NX
Colon	9 NX
Liver	7 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	30 NX
Eye	30 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	18 NX
Pancreas	18 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	25 NX
Prostate	49 NX
Heart muscle	27 NX
Skin	26 NX
Eye	25 NX
Testis	21 NX
Lung	20 NX
Placenta	18 NX
Liver	18 NX
Pancreas	11 NX

Enterocytes	14 NX
Rectum	23 NX
Colon	18 NX
Small intestine	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	12 NX
Prostate	24 NX
Skin	24 NX
Heart muscle	22 NX
Lung	12 NX
Placenta	9 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	17 NX
Colon	18 NX
Lung	16 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	13 NX
Placenta	13 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	17 NX
Rectum	21 NX
Colon	14 NX

Ito cells	11 NX
Liver	11 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	73 NX
Testis	73 NX

Macrophages	17 NX
Lung	40 NX
Skin	21 NX
Prostate	14 NX
Testis	14 NX
Pancreas	12 NX
Kidney	12 NX

Melanocytes	5 NX
Skin	5 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	6 NX
Pancreas	6 NX

Mucus-secreting cells	22 NX
Rectum	25 NX
Colon	18 NX
Small intestine	10 NX

Muller glia cells	7 NX
Eye	7 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	16 NX
Colon	20 NX
Rectum	16 NX
Small intestine	4 NX

Peritubular cells	40 NX
Testis	40 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	3 NX
Eye	3 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	12 NX
Pancreas	23 NX
Prostate	12 NX
Heart muscle	12 NX
Skin	11 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	7 NX
Placenta	7 NX

T-cells	5 NX
Lung	7 NX
Liver	6 NX
Skin	5 NX
Prostate	4 NX
Colon	4 NX
Kidney	1 NX

Undifferentiated cells	17 NX
Rectum	23 NX
Colon	16 NX
Small intestine	13 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.