Cell type atlas - RNF19A - The Human Protein Atlas

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RNF19A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF19A
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 19A, RBR E3 ubiquitin protein ligase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	39 NX
Lung	39 NX

B-cells	24 NX
Colon	64 NX
Kidney	27 NX
Liver	17 NX

Basal glandular cells	85 NX
Prostate	85 NX

Basal keratinocytes	36 NX
Skin	36 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	35 NX
Heart muscle	35 NX

Cholangiocytes	84 NX
Liver	84 NX

Ciliated cells	108 NX
Lung	108 NX

Club cells	101 NX
Lung	101 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	57 NX
Eye	57 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	52 NX
Pancreas	52 NX

Early spermatids	152 NX
Testis	152 NX

Endothelial cells	53 NX
Eye	77 NX
Prostate	68 NX
Heart muscle	59 NX
Lung	53 NX
Pancreas	50 NX
Testis	46 NX
Skin	44 NX
Liver	29 NX
Placenta	20 NX

Enterocytes	39 NX
Small intestine	44 NX
Rectum	42 NX
Colon	39 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	35 NX
Pancreas	35 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	45 NX
Heart muscle	67 NX
Skin	66 NX
Lung	48 NX
Prostate	45 NX
Placenta	20 NX

Glandular cells	62 NX
Prostate	62 NX

Granulocytes	41 NX
Lung	63 NX
Colon	18 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	20 NX
Placenta	20 NX

Horizontal cells	56 NX
Eye	56 NX

Intestinal endocrine cells	20 NX
Colon	31 NX
Rectum	9 NX

Ito cells	31 NX
Liver	31 NX

Kupffer cells	28 NX
Liver	28 NX

Late spermatids	203 NX
Testis	203 NX

Leydig cells	54 NX
Testis	54 NX

Macrophages	30 NX
Prostate	38 NX
Skin	36 NX
Lung	34 NX
Kidney	27 NX
Testis	24 NX
Pancreas	7 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	9 NX
Pancreas	9 NX

Mucus-secreting cells	22 NX
Colon	29 NX
Small intestine	19 NX
Rectum	18 NX

Muller glia cells	41 NX
Eye	41 NX

Pancreatic endocrine cells	43 NX
Pancreas	43 NX

Paneth cells	25 NX
Colon	43 NX
Small intestine	25 NX
Rectum	18 NX

Peritubular cells	65 NX
Testis	65 NX

Proximal tubular cells	43 NX
Kidney	43 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	28 NX
Prostate	39 NX
Heart muscle	38 NX
Skin	27 NX
Pancreas	13 NX

Spermatocytes	63 NX
Testis	63 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	53 NX
Skin	53 NX

Syncytiotrophoblasts	7 NX
Placenta	7 NX

T-cells	48 NX
Skin	201 NX
Colon	192 NX
Lung	144 NX
Prostate	126 NX
Liver	44 NX
Kidney	43 NX

Undifferentiated cells	18 NX
Colon	24 NX
Rectum	18 NX
Small intestine	18 NX

Urothelial cells	102 NX
Prostate	102 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.