Cell type atlas - GRN - The Human Protein Atlas

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GRN

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GRN
Gene descriptionⁱ Full gene name according to HGNC.	Granulin precursor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, myeloid DC, plasmacytoid DC, intermediate monocyte, neutrophil, non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	77 NX
Lung	77 NX

B-cells	97 NX
Colon	118 NX
Liver	81 NX
Kidney	76 NX

Basal glandular cells	125 NX
Prostate	125 NX

Basal keratinocytes	100 NX
Skin	100 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	75 NX
Heart muscle	75 NX

Cholangiocytes	117 NX
Liver	117 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	66 NX
Lung	66 NX

Collecting duct cells	208 NX
Kidney	208 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	351 NX
Placenta	351 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	337 NX
Pancreas	337 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	135 NX
Placenta	293 NX
Pancreas	218 NX
Liver	214 NX
Testis	158 NX
Eye	128 NX
Lung	125 NX
Skin	119 NX
Heart muscle	116 NX
Prostate	83 NX

Enterocytes	311 NX
Rectum	508 NX
Colon	433 NX
Small intestine	251 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	271 NX
Pancreas	271 NX

Extravillous trophoblasts	268 NX
Placenta	268 NX

Fibroblasts	138 NX
Placenta	272 NX
Skin	135 NX
Heart muscle	90 NX
Prostate	61 NX
Lung	49 NX

Glandular cells	80 NX
Prostate	80 NX

Granulocytes	75 NX
Colon	101 NX
Lung	49 NX

Hepatocytes	71 NX
Liver	71 NX

Hofbauer cells	1369 NX
Placenta	1369 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	120 NX
Rectum	140 NX
Colon	99 NX

Ito cells	213 NX
Liver	213 NX

Kupffer cells	737 NX
Liver	737 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	553 NX
Pancreas	1593 NX
Prostate	903 NX
Lung	726 NX
Kidney	620 NX
Testis	417 NX
Skin	395 NX

Melanocytes	197 NX
Skin	197 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	402 NX
Pancreas	402 NX

Mucus-secreting cells	200 NX
Colon	214 NX
Rectum	200 NX
Small intestine	158 NX

Muller glia cells	69 NX
Eye	69 NX

Pancreatic endocrine cells	249 NX
Pancreas	249 NX

Paneth cells	497 NX
Colon	616 NX
Rectum	497 NX
Small intestine	459 NX

Peritubular cells	54 NX
Testis	54 NX

Proximal tubular cells	96 NX
Kidney	96 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	74 NX
Pancreas	150 NX
Skin	76 NX
Prostate	74 NX
Heart muscle	45 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	84 NX
Skin	84 NX

Syncytiotrophoblasts	535 NX
Placenta	535 NX

T-cells	32 NX
Lung	106 NX
Skin	42 NX
Prostate	39 NX
Liver	32 NX
Kidney	27 NX
Colon	20 NX

Undifferentiated cells	196 NX
Rectum	305 NX
Colon	262 NX
Small intestine	140 NX

Urothelial cells	159 NX
Prostate	159 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.