Cell type atlas - IFNGR1 - The Human Protein Atlas

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IFNGR1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IFNGR1
Gene descriptionⁱ Full gene name according to HGNC.	Interferon gamma receptor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Disease related genes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTCEpi)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	75 NX
Lung	75 NX

Alveolar cells type 2	64 NX
Lung	64 NX

B-cells	58 NX
Kidney	80 NX
Colon	73 NX
Liver	36 NX

Basal glandular cells	146 NX
Prostate	146 NX

Basal keratinocytes	113 NX
Skin	113 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	38 NX
Heart muscle	38 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	83 NX
Lung	83 NX

Club cells	77 NX
Lung	77 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	63 NX
Placenta	63 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	62 NX
Pancreas	62 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	106 NX
Heart muscle	210 NX
Eye	125 NX
Testis	125 NX
Lung	117 NX
Prostate	96 NX
Skin	71 NX
Placenta	57 NX
Liver	54 NX
Pancreas	32 NX

Enterocytes	70 NX
Rectum	97 NX
Small intestine	71 NX
Colon	54 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	88 NX
Pancreas	88 NX

Extravillous trophoblasts	59 NX
Placenta	59 NX

Fibroblasts	71 NX
Prostate	108 NX
Skin	83 NX
Heart muscle	77 NX
Lung	64 NX
Placenta	48 NX

Glandular cells	89 NX
Prostate	89 NX

Granulocytes	61 NX
Lung	67 NX
Colon	55 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	133 NX
Placenta	133 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	13 NX
Colon	14 NX
Rectum	12 NX

Ito cells	64 NX
Liver	64 NX

Kupffer cells	259 NX
Liver	259 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	249 NX
Testis	501 NX
Skin	287 NX
Prostate	263 NX
Pancreas	236 NX
Lung	217 NX
Kidney	168 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	88 NX
Pancreas	88 NX

Mucus-secreting cells	19 NX
Small intestine	25 NX
Colon	21 NX
Rectum	18 NX

Muller glia cells	20 NX
Eye	20 NX

Pancreatic endocrine cells	74 NX
Pancreas	74 NX

Paneth cells	28 NX
Colon	98 NX
Rectum	28 NX
Small intestine	28 NX

Peritubular cells	46 NX
Testis	46 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	21 NX
Eye	21 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	65 NX
Skin	83 NX
Prostate	79 NX
Heart muscle	65 NX
Pancreas	46 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	99 NX
Skin	99 NX

Syncytiotrophoblasts	176 NX
Placenta	176 NX

T-cells	68 NX
Prostate	109 NX
Lung	89 NX
Liver	75 NX
Colon	68 NX
Skin	65 NX
Kidney	61 NX

Undifferentiated cells	28 NX
Colon	35 NX
Small intestine	28 NX
Rectum	23 NX

Urothelial cells	145 NX
Prostate	145 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.